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Delgado, Daniel Ricardo Castro-Camacho, Jennifer Katiusca Ortiz, Claudia Caviedes Rubio, Diego Ivan Martinez, Fleming Grupo de Investigación de Ingenierías UCC-Neiva Mundial 2024-12-10T16:08:07Z 2024-12-10T16:08:07Z 2024-11-26 MDPI and ACS Style Delgado, D.R.; Castro-Camacho, J.K.; Ortiz, C.P.; Caviedes-Rubio, D.I.; Martinez, F. Dissolution Thermodynamics of the Solubility of Sulfamethazine in (Acetonitrile + 1-Propanol) Mixtures. Pharmaceuticals 2024, 17, 1594. https://doi.org/10.3390/ph17121594 AMA Style Delgado DR, Castro-Camacho JK, Ortiz CP, Caviedes-Rubio DI, Martinez F. Dissolution Thermodynamics of the Solubility of Sulfamethazine in (Acetonitrile + 1-Propanol) Mixtures. Pharmaceuticals. 2024; 17(12):1594. https://doi.org/10.3390/ph17121594 Chicago/Turabian Style Delgado, Daniel Ricardo, Jennifer Katiusca Castro-Camacho, Claudia Patricia Ortiz, Diego Ivan Caviedes-Rubio, and Fleming Martinez. 2024. "Dissolution Thermodynamics of the Solubility of Sulfamethazine in (Acetonitrile + 1-Propanol) Mixtures" Pharmaceuticals 17, no. 12: 1594. https://doi.org/10.3390/ph17121594 APA Style Delgado, D. R., Castro-Camacho, J. K., Ortiz, C. P., Caviedes-Rubio, D. I., & Martinez, F. (2024). Dissolution Thermodynamics of the Solubility of Sulfamethazine in (Acetonitrile + 1-Propanol) Mixtures. Pharmaceuticals, 17(12), 1594. https://doi.org/10.3390/ph17121594 1424-8247 https://hdl.handle.net/20.500.12494/57840 doi.org/10.3390/ph17121594 Background: Solubility is one of the most important parameters in the research and development processes of the pharmaceutical industry. In this context, cosolubility is one of the most used strategies to improve the solubility of poorly soluble drugs, besides allowing to identify some factors involved in the dissolution process. The aim of this research is to evaluate the solubility of sulfamethazine in acetotinitrile + 1-propanol cosolvent mixtures at 9 temperatures (278.15, 283.15, 288.15, 293.15, 298.15, 303.15, 308.15, 313.15, and 318.15 K); a drug used in human and veterinary therapy and two solvents of great chemical–pharmaceutical interest. Methods: The determination was carried out by the shaking flask method and the drug was quantified by UV/Vis spectrophotometry. Results: The solubility of sulfamethazine increases from pure 1-propanol (solvent in which it reaches its lowest solubility at 278.15 K) to pure acetonitrile (solvent in which it reaches its maximum solubility at 318.15 K), behaving in a logarithmic-linear fashion. Conclusions: The increase in solubility is related to the acid/base character of the cosolvent mixtures and not to the solubility parameter of the mixtures. The dissolution process is endothermic and favored by the solution entropy, and also shows a strong entropic compensation. Universidad Cooperativa de Colombia Financiación en dinero y especie Energías, agua y medio ambiente pdf application/pdf eng Universidad Cooperativa de Colombia Neiva Creative Commons Attribution (CC BY) http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess Attribution 4.0 International http://purl.org/coar/access_right/c_abf2 https://www.mdpi.com/1424-8247/17/12/1594 540 - Química y ciencias afines sulfamethazine solubility acetonitrile 1-propanol cosolvency solution thermodynamics Dissolution Thermodynamics of the Solubility of Sulfamethazine in (Acetonitrile + 1-Propanol) Mixtures Artículo de revista http://purl.org/coar/resource_type/c_6501 http://purl.org/coar/version/c_970fb48d4fbd8a85 Text info:eu-repo/semantics/article http://purl.org/redcol/resource_type/ART info:eu-repo/semantics/publishedVersion 16 12 1 17 Davis, K.J.; Athira, K. Chapter 24: Infectious Abortive Diseases. 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