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oai:repository.ucc.edu.co:20.500.12494/466372024-08-20T21:19:41Zcom_20.500.12494_36578com_20.500.12494_36577col_20.500.12494_41230

Delgado, Daniel Ricardo Vargas-Santana, Martha Sofía Cruz-González, Ana María Ortiz, Claudia Patricia Delgado, Daniel Ricardo Martínez, Fleming Peña, María Ángeles Acree Jr., William E. Jouyban, Abolghasem 337 2022-10-06T20:04:12Z 2024-12-01 2022-10-06T20:04:12Z 2021-09-01 0167-7322 10.1016/j.molliq.2021.116330 https://hdl.handle.net/20.500.12494/46637 Solubility of sulfamerazine in (ethylene glycol+ water) mixtures: Measurement, correlation, dissolution thermodynamics and preferential solvation MS Vargas-Santana, AM Cruz-González, CP Ortiz, DR Delgado, ... Journal of Molecular Liquids 337, 116330 La solubilidad en equilibrio de la sulfamerazina (SMR) en etilenglicol puro (EG) y diecinueve {(EG) (1) + agua (2)} mezclas se reporta a temperaturas de (278.15 a 318.15) K. Solubilidad en fracción molar de SMR ( x 3 ) aumenta con el aumento de la temperatura y también aumenta con el aumento de la proporción de EG. Varía de 1,71 × 10 −5 en agua pura a 7,78 × 10 −4en EG puro a 298,15 K. El comportamiento de la solubilidad se correlacionó mediante el modelo logarítmico lineal extendido de Yalkowsky, el modelo Jouyban-Acree y el modelo Jouyban-Acree-van't Hoff y las desviaciones porcentuales medias obtenidas son 80,1 %, 6,7 % y 6,6%, respectivamente. A partir de la variación de la solubilidad con la temperatura, se realizó el análisis termodinámico aparente de los procesos de disolución y mezcla en todas las mezclas y solventes puros. A partir de los cálculos de integrales inversas de Kirkwood-Buff (IKBI) se observa que SMR exhibe parámetros de solvatación preferenciales negativos bajos por EG en mezclas ricas en agua. De lo contrario, SMR se solvata preferentemente por EG en el intervalo (0.24 < x 1 < 1.00). The equilibrium solubility of sulfamerazine (SMR) in neat ethylene glycol (EG) and nineteen {(EG) (1) + water (2)} mixtures is reported at temperatures from (278.15 to 318.15) K. Mole fraction solubility of SMR (x3) increases with temperature arising and also increases with the EG proportion increasing. It varies from 1.71 × 10−5 in neat water to 7.78 × 10−4 in neat EG at 298.15 K. Solubility behavior was correlated by the extended log-linear model of Yalkowsky, the Jouyban-Acree model, and Jouyban-Acree-van’t Hoff model and the obtained mean percentage deviations are 80.1%, 6.7% and 6.6%, respectively. From the variation of solubility with temperature, the apparent thermodynamic analysis of dissolution and mixing processes was performed in all the mixtures and neat solvents. From inverse Kirkwood-Buff integrals (IKBI) calculations is observed that SMR exhibits low negative preferential solvation parameters by EG in water-rich mixtures. Otherwise, SMR is preferentially solvated by EG in the interval (0.24 < x1 < 1.00). Highlights Abstract Keywords 1. Introduction 2. Experimental 3. Results and discussion 4. Conclusions CRediT authorship contribution statement Declaration of Competing Interest Acknowledgements Appendix A. Supplementary material References https://scienti.minciencias.gov.co/cvlac/visualizador/generarCurriculoCv.do?cod_rh=0001402116 https://orcid.org/0000-0002-4835-9739 https://scienti.minciencias.gov.co/gruplac/jsp/visualiza/visualizagr.jsp?nro=00000000004151 danielr.delgado@campusucc.edu.co https://scholar.google.com/citations?hl=es&user=OW0mejcAAAAJ&view_op=list_works&sortby=pubdate 15 Universidad Cooperativa de Colombia, Facultad de Ingenierías, Ingeniería Civil, Neiva Elsevier Ingeniería Civil Neiva https://www.sciencedirect.com/science/article/abs/pii/S0167732221010540#! Journal of Molecular Liquids J.T. Rubino, Cosolvents and cosolvency, in: J.C. Swarbrick, J. Boylan (editors), Encyclopedia of Pharmaceutical Technology, Marcel Dekker, New York (NY), 1988, vol. 3, p. 375-398. S.H. 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Marcus Preferential solvation of drugs in binary solvent mixtures Pharm. Anal. Acta, 8 (2017), p. 1000537 D.R. Delgado, F. Martínez Solubility and solution thermodynamics of sulfamerazine and sulfamethazine in some ethanol + water mixtures Fluid Phase Equilib., 360 (2013), pp. 88-96 D.R. Delgado, F. Martínez Solubility and solution thermodynamics of some sulfonamides in 1-propanol + water mixtures J. Solution Chem., 43 (2014), pp. 836-852 sulfamerazina {Etilenglicol (1) + agua (2)} mezclas Solubilidad Modelo Jouyban-Acree Solucion preferencial IKBI Q1 Sulfamerazine {Ethylene glycol (1) + water (2)} mixtures Solubility Jouyban-Acree model Preferential solvation IKBI Solubility of sulfamerazine in (ethylene glycol + water) mixtures: Measurement, correlation, dissolution thermodynamics and preferential solvation Artículo http://purl.org/coar/resource_type/c_6501 http://purl.org/coar/version/c_970fb48d4fbd8a85 info:eu-repo/semantics/article http://purl.org/redcol/resource_type/ART info:eu-repo/semantics/publishedVersion Atribución – No comercial info:eu-repo/semantics/closedAccess http://purl.org/coar/access_right/c_14cb Publicationopen.access