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Romero Nieto, Alba Miledy Cerquera, Néstor Enrique Martínez, Fleming Delgado, Daniel Ricardo Vol. 287 2019-12-16T22:57:43Z 2019-12-16T22:57:43Z 2019-08-01 https://doi.org/10.1016/j.molliq.2019.110894 https://hdl.handle.net/20.500.12494/15766 Alba Miledy Romero-Nieto, Nestor Enrique Cerquera, Fleming Martínez, Daniel Ricardo Delgado, Thermodynamic study of the solubility of ethylparaben in acetonitrile+ water cosolvent mixtures at different temperatures, Journal of Molecular Liquids Volume 287, 1 August 2019, 110894 The thermodynamic analysis of the solubility of ethylparaben (1) in acetonitrile (1) + water (2) cosolvent mixtures at 9 temperatures, 10 cosolvent mixtures and the 2 pure solvents, water and acetonitrile, is reported herein. The solution thermodynamic functions were calculated from the experimental solubility data, using the van't Hoff and Gibbs equations, following the approach proposed by Krug et al. Thus, the solubility of ethylparaben is thermo-dependent, reaching its minimum value in pure water at 278.15 K and its maximum value in the cosolvent mixture w1 = 0.90 at 318.18 K. The enthalpy of solution is positive in all cases, which is an indication of the endothermic process, with an enthalpy-driven mixing process in mixtures rich in water and by entropy mixtures rich in acetonitrile. The thermodynamic analysis of the solubility of ethylparaben (1) in acetonitrile (1) + water (2) cosolvent mixtures at 9 temperatures, 10 cosolvent mixtures and the 2 pure solvents, water and acetonitrile, is reported herein. The solution thermodynamic functions were calculated from the experimental solubility data, using the van't Hoff and Gibbs equations, following the approach proposed by Krug et al. Thus, the solubility of ethylparaben is thermo-dependent, reaching its minimum value in pure water at 278.15 K and its maximum value in the cosolvent mixture w1 = 0.90 at 318.18 K. The enthalpy of solution is positive in all cases, which is an indication of the endothermic process, with an enthalpy-driven mixing process in mixtures rich in water and by entropy mixtures rich in acetonitrile. Highlights. -- Abstract. -- Keywords. -- 1. Introduction. -- 2. Experimental. -- 2.1. Reagents. -- 2.2. Preparation of the solvent mixture. -- 2.3. Determination of solubility. -- 3. Results and discussion. -- 3.1. Solubility of ethyl paraben in cosolvent mixtures of acetonitrile + water. -- 3.2. Activity coefficients of ethylparaben. -- 3.3. Thermodynamic functions of solution. -- 3.4. Thermodynamic functions of ethylparaben transfer. -- 3.5. Thermodynamic functions of the ethylparaben mixture. -- 3.6. Enthalpy–entropy compensation. -- 4. 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Prankerd Solid-state properties of drugs. I. Estimation of heat capacities for fusion and thermodynamic functions for solution from aqueous solubility-temperature dependence measurements Int. J. Pharm., 84 (1992), pp. 233-244 Thermodynamic analysis Cosolvent mixture Ethylparaben Acetonitrile Solubility Thermodynamic analysis Cosolvent mixture Ethylparaben Acetonitrile Solubility Thermodynamic study of the solubility of ethylparaben in acetonitrile + water cosolvent mixtures at different temperatures Artículo http://purl.org/coar/resource_type/c_6501 http://purl.org/coar/version/c_970fb48d4fbd8a85 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Atribución – No comercial – Sin Derivar info:eu-repo/semantics/closedAccess http://purl.org/coar/access_right/c_14cb Publicationrestricted