Publicación:
Characterization of the Venom of C. d. cumanesis of Colombia: Proteomic Analysis and Antivenomic Study

dc.contributor.authorQuintana-Castillo, Juan Carlos
dc.contributor.authorVargas-Muñoz, Leidy Johana
dc.contributor.authorVargas, Leidy Johana
dc.contributor.authorSegura, Cesar
dc.contributor.authorEstrada-Gómez, Sebastián
dc.contributor.authorBueno-Sánchez, Julio César
dc.contributor.authorAlarcón, Juan Carlos
dc.coverage.temporal10es
dc.date.accessioned2020-01-15T15:24:30Z
dc.date.available2020-01-15T15:24:30Z
dc.date.issued2018-02-17
dc.description.abstractThe Colombian rattlesnake Crotalus durissus cumanensis is distributed in three geographic zones of the country: the Atlantic Coast, the upper valley of the Magdalena River, and the eastern plains of the Colombian Orinoquía. Its venom induces neurological symptoms, such as eyelid ptosis, myasthenic facies, and paralysis of the respiratory muscles, which can lead to death. Identification and analysis of C. d. cumanensis showed nine groups of proteins responsible for the neurotoxic effect, of which the crotoxin complex was the most abundant (64.71%). Immunorecognition tests of C. d. cumanensis showed that the use of a commercial antivenom manufactured in Mexico resulted in immunoreactivity.es
dc.description.cvlachttps://scienti.colciencias.gov.co/cvlac/visualizador/generarCurriculoCv.do?cod_rh=0000580023es
dc.description.emailjuan.quintanac@campusucc.edu.coes
dc.description.emailleidy.vargasmu@campusucc.edu.coes
dc.description.emailcesar.segura@udea.edu.coes
dc.description.emailsebastian.estrada@udea.edu.coes
dc.description.emailjulio.bueno@udea.edu.coes
dc.description.emailjuan.alarcon@udea.edu.coes
dc.format.extent12es
dc.identifier.bibliographicCitationQuintana-Castillo, J.C., Vargas, L.J., Segura, C., Estrada-Gómez, S., Bueno-Sánchez, J.C. y Alarcón, J.C. (2018). Characterization of the Venom of C. d. cumanesis of Colombia: Proteomic Analysis and Antivenomic Study. Toxins 2018, 10, 85. Recuperado de:es
dc.identifier.issn2072-6651es
dc.identifier.uri10.3390/toxins10020085es
dc.identifier.urihttps://hdl.handle.net/20.500.12494/15917
dc.publisherUniversidad Cooperativa de Colombia, Facultad de Ciencias de la Salud, Medicina, Medellín y Envigadoes
dc.publisher.placeMedellínes
dc.publisher.programMedicinaes
dc.relation.ispartofjournalToxinses
dc.relation.isversionofhttps://www.mdpi.com/2072-6651/10/2/85es
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dc.rights.accessrightsinfo:eu-repo/semantics/closedAccesses
dc.rights.licenseAtribución – No comercial – Sin Derivares
dc.subjectC. d. cumanensis venomes
dc.subjectantivenomes
dc.subjectHPLC-nESI-MS/MSes
dc.subjectpeptide identificationes
dc.titleCharacterization of the Venom of C. d. cumanesis of Colombia: Proteomic Analysis and Antivenomic Studyes
dc.typeArtículo
dspace.entity.typePublication

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