Publicación: Reabsorción radicular externa en pacientes tratados ortodonticamente y su relación con polimorfismos genéticos
dc.contributor.advisor | Delgado Perdomo, Linda Piedad | |
dc.contributor.advisor | Ruiz Gomez, Adiela | |
dc.contributor.author | Herrera Fandiño, Leidy Johana | |
dc.contributor.author | Artunduaga Imbachi, Mónica Isabel | |
dc.date.accessioned | 2021-02-16T18:45:17Z | |
dc.date.available | 2021-02-16T18:45:17Z | |
dc.date.issued | 2020-11-27 | |
dc.description | La reabsorción radicular externa (RRE) presente en pacientes con tratamiento de ortodoncia ha sido relacionada con factores biológicos o internos y factores medioambientales o externos; dentro de los primeros, diferentes polimorfismos genéticos han sido estudiados sin embargo los resultados son inconsistentes. Objetivo: valorar evidencia científica actualizada sobre RRE en pacientes tratados ortodonticamente y su relación con los polimorfismos genéticos. Metodología: la revisión bibliográfica abarcó el periodo comprendido entre enero de 2010 y enero de 2020. Se consultaron varias fuentes de información en formato digital, bases de datos bibliográficos de la Universidad Cooperativa de Colombia, PubMed, Medline además del buscador Google académico en el que se empleó la estrategia de búsqueda avanzada; para la selección de los artículos, se tuvo en cuenta el criterio de actualidad, últimos 10 años. Resultados: sobre la base de la búsqueda se identificaron un total de 15 estudios relacionados con el tema. Publicaciones encontradas identificaron como posible factor de riesgo para la RRE en pacientes con ortodoncia la presencia de los siguientes polimorfismos: IL-6 (rs1800796), IL-1β (+3954) o (rs1143634), osteopontina (rs9138) y el receptor TaqI de la vitamina D (rs731236). Es necesario realizar más estudios experimentales en seres humanos con el fin de aumentar la evidencia de esta posible asociación Conclusiones: se necesita más investigación sobre la relación entre la RRE y los polimorfismos genéticos en pacientes con ortodoncia para determinar una mejor especificidad de las posibles interacciones. | es |
dc.description.abstract | The relationship between external root resorption and genetic polymorphisms in patients treated with orthodontics, has generated a growing interest in the subject, due to the interrelation that exists between them; External root resorption has been observed in 35% with the presence of a greater or lesser proportion of genetic polymorphisms. Objective: to evaluate updated scientific evidence on external root resorption in orthodontically treated patients and its relationship with genetic polymorphisms. Methodology: the bibliographic review was carried out during the months of January 2010 to January 2020. Several sources of information were consulted in digital format, bibliographic databases in the library of the Cooperative University of Colombia, in PubMed, Medline in addition to the search engine Academic Google in which the advanced search strategy was used, for the selection of articles, current criteria were taken into account, the last 10 years. Results: on the basis of the search, a total of 15 studies related to the topic were identified. Publications found of cases and controls identified as risk factor for external root resorption and orthodontia the polymorphisms IL-6 SNP rs1800796 GC, the polymorphism IL-1β +3954 C> T (rs1143634), Osteopontin (rs9138) receptor enzyme TaqI vitamin D polymorphism (rs731236). It is necessary to carry out experimental studies in humans in order to further clarify the real characteristics of this possible association. Conclusions: More research is needed on the relationship between genetic polymorphism and external root resorption to determine a better specificity of the possible interactions. | es |
dc.description.email | leidy.herreraf@campusucc.edu.co | es |
dc.description.email | monica.artunduaga@campusucc.edu.co | es |
dc.description.tableofcontents | Lista de tablas. -- Lista de ilustraciones. -- Lista de anexos. -- Introducción. -- Capitulo i. Tema de investigación. -- 1.1. Delimitación del tema. -- 1.1.1. Ubicación témporo-espacial del tema. -- 1.1.2. Aspectos a ser analizados. -- 1.2. Marco teórico o conceptual. -- 1.3. Objetivos. -- 1.3.1. General. -- 1.3.2. Específicos. -- 1.4. Justificación. -- Capitulo 2. Metodología. -- 2.1. Tipo de estudio. -- 2.2. Búsqueda de literatura. -- 2.2.1. Bases de datos y fuentes de información. -- 2.2.1.1. Primarias. -- 2.2.1.2. Secundarias. -- 2.2.1.3. Terciarias. -- 2.2.2. Estrategia de búsqueda. -- 2.2.3. Registro de información. -- 2.2.4. Flujograma de información. -- Capitulo 3. Resultados. -- 3.1. Reabsorción radicular externa y movimiento dental ortodontico. -- 3.1.1. Generalidades de reabsorción radicular externa. -- 3.1.2. Fisiopatología de la reabsorción radicular externa. -- 3.1.3. Factores asociados con la reabsorción radicular externa. -- 3.2. Polimorfismos genéticos y ortodoncia. -- 3.2.1. Polimorfismos genéticos frecuentes en movimientos ortodónticos. -- 3.3. Relación entre reabsorción radicular externa y polimorfismos en ortodoncia. -- 3.4. Polimorfismos genéticos frecuentes que predisponen la reabsorción radicular en el tratamiento ortodóntico. -- Capitulo 4. Conclusiones. -- Bibliografia. | es |
dc.identifier.bibliographicCitation | Herrera Fandiño, L. J. y Artunduaga Imbachi, M. I. (2020). Reabsorción radicular externa en pacientes tratados ortodonticamente y su relación con polimorfismos genéticos [Tesis de Especialización, Universidad Cooperativa de Colombia] Repositorio Institucional UCC. | es |
dc.identifier.uri | https://hdl.handle.net/20.500.12494/33409 | |
dc.publisher | Universidad Cooperativa de Colombia, Facultad de Ciencias de la Salud, Especialización en Ortodoncia, Bogotá | es |
dc.publisher.place | Bogotá | es |
dc.publisher.program | Especialización en Ortodoncia | es |
dc.relation.references | Kunii R, Yamaguchi M, Tanimoto Y, Asano M, Yamada K, Goseki T, et al. Role of interleukin-6 in orthodontically induced inflammatory root resorption in humans. Korean J Orthod. 2013;43(6):294–301. 2. Masella RS, Meister M. Current concepts in the biology of orthodontic tooth movement. Am J Orthod Dentofac Orthop. 2006 Apr;129(4):458–68. 3. Iglesias-Linares A, Yañez-Vico R, Ballesta-Mudarra S, Ortiz-Ariza E, Ortega-Rivera H, Mendoza-Mendoza A, et al. Postorthodontic external root resorption is associated with IL1 receptor antagonist gene variations. Oral Dis. 2012 Mar;18(2):198–205. 4. Iglesias-Linares A, Yañez-Vico RM, Ballesta S, Ortiz-Ariza E, Mendoza-Mendoza A, Perea E, et al. Interleukin 1 gene cluster SNPs (rs1800587, rs1143634) influences post-orthodontic root resorption in endodontic and their contralateral vital control teeth differently. Int Endod J. 2012 Nov;45(11):1018–26. 5. Al-Qawasmi RA, Hartsfield JK, Everett ET, Flury L, Liu L, Foroud TM, et al. Genetic predisposition to external apical root resorption. Am J Orthod Dentofac Orthop. 2003;123(3):242–52. 6. Ngan DCS, Kharbanda OP, Byloff FK, Darendeliler MA. The genetic contribution to orthodontic root resorption: a retrospective twin study. Aust Orthod J. 2004 May;20(1):1–9. 7. Hughes AE, Ralston SH, Marken J, Bell C, MacPherson H, Wallace RGH, et al. Mutations in TNFRSF11A, affecting the signal peptide of RANK, cause familial expansile osteolysis. Nat Genet. 2000;24(1):45–8. 8. Sharab LY, Morford LA, Dempsey J, Falcão-Alencar G, Mason A, Jacobson E, et al. Genetic and treatment-related risk factors associated with external apical root resorption (EARR) concurrent with orthodontia. Orthod Craniofacial Res. 2015 Apr 1;18(S1):71–82. 9. Beertsen W, Vandenbos T, Everts V. Root Development in Mice Lacking Functional Tissue Non-specific Alkaline Phosphatase Gene: Inhibition of Acellular Cementum Formation. J Dent Res. 1999;78(6):1221–9. 10. Le J, Vilcek J. Tumor necrosis factor and interleukin 1: Cytokines with multiple overlapping biological activities. Lab Investig. 1987;56(3):234–48. 11. Vaquero Niño, Paula, Perea Pérez, Bernardo, Labajo González, Elena, Santiago Sáez, Andrés y García Marín F. Reabsorción radicular durante el tratamiento ortodóncico : causas y recomendaciones de actuación. Cient dent. 2011;8(1):61–70. 12. Lee YJ, Lee TY. External root resorption during orthodontic treatment in root-filled teeth and contralateral teeth with vital pulp: A clinical study of contributing factors. Am J Orthod Dentofac Orthop. 2016;149(1):84–91. 13. Blake M, Woodside DG, Pharoah MJ. A radiographic comparison of apical root resorption after orthodontic treatment with the edgewise and Speed appliances. Am J Orthod Dentofac Orthop. 1995;108(1):76–84. 14. Guo Y, He S, Gu T, Liu Y, Chen S. Genetic and clinical risk factors of root resorption associated with orthodontic treatment. Am J Orthod Dentofac Orthop. 2016;150(2):283–9. 15. Fernández R, Tobón D, Osorno K, Zuluaga O. Polimorfismo genetico para la interleukina-1ß como modulador de los procesos de reabsorción ósea Rafael. Rev CES Odontol ISSN. 2012;25(1):92–101. 16. Burstone C.J., K. C. The Biomechanical Foundation of Clinical Orthodontics. In 2015. p. 512–32. 17. Herrera C, Montesinos F, Meléndez O. Apical root resorption incidence in finished cases of the Orthodontics Department of the Postgraduate Studies and Research Division of the Faculty of Dentistry, UNAM, during the 2010-2012 period. Rev Mex Ortod. 2015;3(3):e175–84. 18. Malmgren O, Goldson L, Hill C, Orwin A, Petrini L, Lundberg M. Root resorption after orthodontic treatment of traumatized teeth. Am J Orthod. 1982 Dec 1;82(6):487–91. 19. Freilich LS. Ultrastructure and Acid Phosphatase Cytochemistry of Odontoclasts: Effects of Parathyroid Extract. J Dent Res. 1971 Sep 8;50(5):1046–55. 20. Brudvik P, Rygh P. Root resorption beneath the main hyalinized zone. Eur J Orthod. 1994 Aug 1;16(4):249–63. 21. Barber AF, Sims MR. Rapid maxillary expansion and external root resorption in man: A scanning electron microscope study. Am J Orthod. 1981;79(6):630–52. 22. Lossdörfer S, Götz W, Jäger A. Immunohistochemical localization of receptor activator of nuclear factor KappaB (RANK) and its ligand (RANKL) in human deciduous teeth. Calcif Tissue Int. 2002 Jul 1;71(1):45–52. 23. Lossdörfer S, Götz W, Jäger A. Localization of IL-1α, IL-1 RI, TNF, TNF-RI and TNF-RII during physiological drift of rat molar teeth - An immunohistochemical and in situ hybridization study. Cytokine. 2002;20(1):7–16. 24. Nowrin SA, Jaafar S, Rahman NAB, Basri R, Alam MK, Shahid F. Association between genetic polymorphisms and external apical root resorption: A systematic review and meta-analysis. Korean J Orthod. 2018 Nov 1;48(6):395–404. 25. Weltman B, Vig KWL, Fields HW, Shanker S, Kaizar EE. Root resorption associated with orthodontic tooth movement: A systematic review. Am J Orthod Dentofac Orthop. 2010 Apr;137(4):462–76. 26. Borges de Castilhos B, Machado de Souza C, Simas Netta Fontana MLS, Pereira FA, Tanaka OM, Trevilatto PC. Association of clinical variables and polymorphisms in RANKL, RANK, and OPG genes with external apical root resorption. Am J Orthod Dentofac Orthop. 2019;155(4):529–42. 27. Aras I, Unal I, Huniler G, Aras A. Root resorption due to orthodontic treatment using self-ligating and conventional brackets: A cone-beam computed tomography study. J Orofac Orthop. 2018 May 1;79(3):181–90. 28. Kurihara N, Bertolini D, Suda T, Akiyama Y, Roodman GD. IL-6 stimulates osteoclast-like multinucleated cell formation in long term human marrow cultures by inducing IL-1 release. J Immunol. 1990 Jun 1;144(11):4226–30. 29. Adebanjo OA, Moonga BS, Yamate T, Sun L, Minkin C, Abe E, et al. Mode of action of interleukin-6 on mature osteoclasts. Novel interactions with extracellular Ca2+ sensing in the regulation of osteoclastic bone resorption. J Cell Biol. 1998 Sep 7;142(5):1347–56. 30. Tomoyasu Y, Yamaguchi T, Tajima A, Inoue I, Maki K. External apical root resorption and the interleukin-1B gene polymorphism in the Japanese population. Orthod Waves. 2009 Dec;68(4):152–7. 31. Aristizábal JF, Ríos H, Rey D, Álvarez MA, Parra Patiño B, Ortiz M. Interleukin 1-beta (IL-1β) polymorphism and orthodontics: a systematic review. Rev Fac Odontol. 2019 Dec 17;31(1–2):147–61. 32. Fontana MLSSN, De Souza CMH, Bernardino JF, Hoette F, Hoette ML, Thum L, et al. Association analysis of clinical aspects and vitamin D receptor gene polymorphism with external apical root resorption in orthodontic patients. Am J Orthod Dentofac Orthop. 2012;142(3):339–47. 33. Wu FL, Wang LY, Huang YQ, Guo WB, Liu CD, Li SG. Interleukin-1β +3954 polymorphisms and risk of external apical root resorption in orthodontic treatment: A meta-analysis. Genet Mol Res. 2013;12(4):4678–86. 34. Pereira S, Nogueira L, Canova F, Lopez M, Silva HC. IRAK1 variant is protective for orthodontic-induced external apical root resorption. Oral Dis. 2016 Oct 1;22(7):658–64. 35. Iglesias-Linares A, Yañez-Vico RM, Moreno-Fernández AM, Mendoza-Mendoza A, Orce-Romero A, Solano-Reina E. Osteopontin gene SNPs (rs9138, rs11730582) mediate susceptibility to external root resorption in orthodontic patients. Oral Dis. 2014;20(3):307–12. 36. Barreto M, Ordóñez P, Blanco M, Lm M, Suárez A, Ga S, et al. Relación entre niveles de IL-1b, TNF-a, IL-6, IL-17a, IL-1RA en fluido crevicular y velocidad de movimiento dental. Estudio Piloto. Pontificia Universidad Javeriana; 2019. 37. Lince Vides F, De La Ossa Salcedo J, Hernandez Tirado R, Buelvas Montes Y, Bustillo Arrieta J, Madera Anaya M. Polimorfismo (+3954C>T) del Gen IL-1B y su Asociación con la Resorción Radicular Apical Externa Post-Tratamiento Ortodóntico. Int J Odontostomatol. 2016;10(2):243–8. 38. Pereira S, Lavado N, Nogueira L, Lopez M, Abreu J, Silva H. Polymorphisms of genes encoding P2X7R, IL-1B, OPG and RANK in orthodontic-induced apical root resorption. Oral Dis. 2014 Oct 1;20(7):659–67. 39. Linhartova P., Cernochova P., Holla LI. IL1 gene polymorphisms in relation to external apical root resorption concurrent with orthodontia. Oral Dis. 2013;19(3):262–70. 40. Linhartova P., Cernochova P., Kastovsky J., Vrankova Z., Sirotkova M., Izakovicova Holla L. Genetic determinants and postorthodontic external apical root resorption in Czech children. Oral Dis. 2017 Jan 1;23(1):29–35. | es |
dc.relation.references | Masella RS, Meister M. Current concepts in the biology of orthodontic tooth | es |
dc.relation.references | Iglesias-Linares A, Yañez-Vico R, Ballesta-Mudarra S, Ortiz-Ariza E, Ortega-Rivera H, Mendoza-Mendoza A, et al. Postorthodontic external root resorption is associated with IL1 receptor antagonist gene variations. Oral Dis. 2012 Mar;18(2):198–205. | es |
dc.relation.references | Iglesias-Linares A, Yañez-Vico RM, Ballesta S, Ortiz-Ariza E, Mendoza-Mendoza A, Perea E, et al. Interleukin 1 gene cluster SNPs (rs1800587, rs1143634) influences post-orthodontic root resorption in endodontic and their contralateral vital control teeth differently. Int Endod J. 2012 Nov;45(11):1018–26. | es |
dc.relation.references | Al-Qawasmi RA, Hartsfield JK, Everett ET, Flury L, Liu L, Foroud TM, et al. Genetic predisposition to external apical root resorption. Am J Orthod Dentofac Orthop. 2003;123(3):242–52. | es |
dc.relation.references | Ngan DCS, Kharbanda OP, Byloff FK, Darendeliler MA. The genetic contribution to orthodontic root resorption: a retrospective twin study. Aust Orthod J. 2004 May;20(1):1–9. | es |
dc.relation.references | Hughes AE, Ralston SH, Marken J, Bell C, MacPherson H, Wallace RGH, et al. Mutations in TNFRSF11A, affecting the signal peptide of RANK, cause familial expansile osteolysis. Nat Genet. 2000;24(1):45–8. | es |
dc.relation.references | Sharab LY, Morford LA, Dempsey J, Falcão-Alencar G, Mason A, Jacobson E, et al. Genetic and treatment-related risk factors associated with external apical root resorption (EARR) concurrent with orthodontia. Orthod Craniofacial Res. 2015 Apr 1;18(S1):71–82. | es |
dc.relation.references | Beertsen W, Vandenbos T, Everts V. Root Development in Mice Lacking Functional Tissue Non-specific Alkaline Phosphatase Gene: Inhibition of Acellular Cementum Formation. J Dent Res. 1999;78(6):1221–9. | es |
dc.relation.references | Le J, Vilcek J. Tumor necrosis factor and interleukin 1: Cytokines with multiple overlapping biological activities. Lab Investig. 1987;56(3):234–48. | es |
dc.relation.references | Vaquero Niño, Paula, Perea Pérez, Bernardo, Labajo González, Elena, Santiago Sáez, Andrés y García Marín F. Reabsorción radicular durante el tratamiento ortodóncico : causas y recomendaciones de actuación. Cient dent. 2011;8(1):61– | es |
dc.relation.references | Lee YJ, Lee TY. External root resorption during orthodontic treatment in root-filled teeth and contralateral teeth with vital pulp: A clinical study of contributing factors. Am J Orthod Dentofac Orthop. 2016;149(1):84–91. | es |
dc.relation.references | Blake M, Woodside DG, Pharoah MJ. A radiographic comparison of apical root resorption after orthodontic treatment with the edgewise and Speed appliances. Am J Orthod Dentofac Orthop. 1995;108(1):76–84. | es |
dc.relation.references | Guo Y, He S, Gu T, Liu Y, Chen S. Genetic and clinical risk factors of root resorption associated with orthodontic treatment. Am J Orthod Dentofac Orthop. 2016;150(2):283–9. 15. | es |
dc.relation.references | Fernández R, Tobón D, Osorno K, Zuluaga O. Polimorfismo genetico para la interleukina-1ß como modulador de los procesos de reabsorción ósea Rafael. Rev CES Odontol ISSN. 2012;25(1):92–101. | es |
dc.relation.references | Burstone C.J., K. C. The Biomechanical Foundation of Clinical Orthodontics. In 2015. p. 512–32. | es |
dc.relation.references | Herrera C, Montesinos F, Meléndez O. Apical root resorption incidence in finished cases of the Orthodontics Department of the Postgraduate Studies and Research Division of the Faculty of Dentistry, UNAM, during the 2010-2012 period. Rev Mex Ortod. 2015;3(3):e175–84. | es |
dc.relation.references | Malmgren O, Goldson L, Hill C, Orwin A, Petrini L, Lundberg M. Root resorption after orthodontic treatment of traumatized teeth. Am J Orthod. 1982 Dec 1;82(6):487–91. | es |
dc.relation.references | Freilich LS. Ultrastructure and Acid Phosphatase Cytochemistry of Odontoclasts: Effects of Parathyroid Extract. J Dent Res. 1971 Sep 8;50(5):1046–55. | es |
dc.relation.references | Brudvik P, Rygh P. Root resorption beneath the main hyalinized zone. Eur J Orthod. 1994 Aug 1;16(4):249–63. | es |
dc.relation.references | Barber AF, Sims MR. Rapid maxillary expansion and external root resorption in man: A scanning electron microscope study. Am J Orthod. 1981;79(6):630–52. | es |
dc.relation.references | Lossdörfer S, Götz W, Jäger A. Immunohistochemical localization of receptor activator of nuclear factor KappaB (RANK) and its ligand (RANKL) in human deciduous teeth. Calcif Tissue Int. 2002 Jul 1;71(1):45–52. | es |
dc.relation.references | Lossdörfer S, Götz W, Jäger A. Localization of IL-1α, IL-1 RI, TNF, TNF-RI and TNF-RII during physiological drift of rat molar teeth - An immunohistochemical and in situ hybridization study. Cytokine. 2002;20(1):7–16. | es |
dc.relation.references | Nowrin SA, Jaafar S, Rahman NAB, Basri R, Alam MK, Shahid F. Association between genetic polymorphisms and external apical root resorption: A systematic review and meta-analysis. Korean J Orthod. 2018 Nov 1;48(6):395–404. | es |
dc.relation.references | Weltman B, Vig KWL, Fields HW, Shanker S, Kaizar EE. Root resorption associated with orthodontic tooth movement: A systematic review. Am J Orthod Dentofac Orthop. 2010 Apr;137(4):462–76. | es |
dc.relation.references | Borges de Castilhos B, Machado de Souza C, Simas Netta Fontana MLS, Pereira FA, Tanaka OM, Trevilatto PC. Association of clinical variables and polymorphisms in RANKL, RANK, and OPG genes with external apical root resorption. Am J Orthod Dentofac Orthop. 2019;155(4):529–42. | es |
dc.relation.references | Aras I, Unal I, Huniler G, Aras A. Root resorption due to orthodontic treatment using self-ligating and conventional brackets: A cone-beam computed tomography study. J Orofac Orthop. 2018 May 1;79(3):181–90. | es |
dc.relation.references | Kurihara N, Bertolini D, Suda T, Akiyama Y, Roodman GD. IL-6 stimulates osteoclast-like multinucleated cell formation in long term human marrow cultures by inducing IL-1 release. J Immunol. 1990 Jun 1;144(11):4226–30. | es |
dc.relation.references | Adebanjo OA, Moonga BS, Yamate T, Sun L, Minkin C, Abe E, et al. Mode of action of interleukin-6 on mature osteoclasts. Novel interactions with extracellular Ca2+ sensing in the regulation of osteoclastic bone resorption. J Cell Biol. 1998 Sep 7;142(5):1347–56. | es |
dc.relation.references | Tomoyasu Y, Yamaguchi T, Tajima A, Inoue I, Maki K. External apical root resorption and the interleukin-1B gene polymorphism in the Japanese population. Orthod Waves. 2009 Dec;68(4):152–7. | es |
dc.relation.references | Aristizábal JF, Ríos H, Rey D, Álvarez MA, Parra Patiño B, Ortiz M. Interleukin 1-beta (IL-1β) polymorphism and orthodontics: a systematic review. Rev Fac Odontol. 2019 Dec 17;31(1–2):147–61. | es |
dc.relation.references | Fontana MLSSN, De Souza CMH, Bernardino JF, Hoette F, Hoette ML, Thum L, et al. Association analysis of clinical aspects and vitamin D receptor gene polymorphism with external apical root resorption in orthodontic patients. Am J Orthod Dentofac Orthop. 2012;142(3):339–47. | es |
dc.relation.references | Wu FL, Wang LY, Huang YQ, Guo WB, Liu CD, Li SG. Interleukin-1β +3954 polymorphisms and risk of external apical root resorption in orthodontic treatment: A meta-analysis. Genet Mol Res. 2013;12(4):4678–86. | es |
dc.relation.references | Pereira S, Nogueira L, Canova F, Lopez M, Silva HC. IRAK1 variant is protective for orthodontic-induced external apical root resorption. Oral Dis. 2016 Oct 1;22(7):658–64. | es |
dc.relation.references | Iglesias-Linares A, Yañez-Vico RM, Moreno-Fernández AM, Mendoza-Mendoza A, Orce-Romero A, Solano-Reina E. Osteopontin gene SNPs (rs9138, rs11730582) mediate susceptibility to external root resorption in orthodontic patients. Oral Dis. 2014;20(3):307–12. | es |
dc.relation.references | Barreto M, Ordóñez P, Blanco M, Lm M, Suárez A, Ga S, et al. Relación entre niveles de IL-1b, TNF-a, IL-6, IL-17a, IL-1RA en fluido crevicular y velocidad de movimiento dental. Estudio Piloto. Pontificia Universidad Javeriana; 2019. | es |
dc.relation.references | Lince Vides F, De La Ossa Salcedo J, Hernandez Tirado R, Buelvas Montes Y, Bustillo Arrieta J, Madera Anaya M. Polimorfismo (+3954C>T) del Gen IL-1B y su Asociación con la Resorción Radicular Apical Externa Post-Tratamiento Ortodóntico. Int J Odontostomatol. 2016;10(2):243–8. | es |
dc.relation.references | Pereira S, Lavado N, Nogueira L, Lopez M, Abreu J, Silva H. Polymorphisms of genes encoding P2X7R, IL-1B, OPG and RANK in orthodontic-induced apical root resorption. Oral Dis. 2014 Oct 1;20(7):659–67. | es |
dc.relation.references | Linhartova P., Cernochova P., Holla LI. IL1 gene polymorphisms in relation to external apical root resorption concurrent with orthodontia. Oral Dis. 2013;19(3):262–70. | es |
dc.relation.references | Linhartova P., Cernochova P., Kastovsky J., Vrankova Z., Sirotkova M., Izakovicova Holla L. Genetic determinants and postorthodontic external apical root resorption in Czech children. Oral Dis. 2017 Jan 1;23(1):29–35. | es |
dc.rights.accessrights | info:eu-repo/semantics/openAccess | es |
dc.rights.license | Atribución – No comercial – Sin Derivar | es |
dc.subject | Reabsorción radicular externa RRE | es |
dc.subject | Ortodoncia | es |
dc.subject | Factores biológicos | es |
dc.subject | Polimorfismo genético | es |
dc.subject | Movimiento dental | es |
dc.subject.classification | TG 2020 EOF | es |
dc.subject.other | External Root Resorption | es |
dc.subject.other | Orthodontic | es |
dc.subject.other | Biological factors | es |
dc.subject.other | Genetic polymorphism | es |
dc.subject.other | Tooth movement | es |
dc.title | Reabsorción radicular externa en pacientes tratados ortodonticamente y su relación con polimorfismos genéticos | es |
dc.type | Trabajos de grado - Posgrados | es |
dspace.entity.type | Publication |
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