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Title: Extended Hildebrand solubility approach applied to some sulphonamides in propylene glycol + water mixtures
Author: Cárdenas, Zaira J.
Jiménez, Daniel M.
Delgado, Daniel Ricardo
Peña, María A.
Martínez, Fleming
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Issue Date: 18-May-2015
Advisor / Validator: Delgado, Daniel Ricardo
Keywords: sulphonamides; propylene glycol; binary mixtures; extended Hildebrand solubility approach; solubility parameter
Resume: Modelamiento matemático
Abstract: Extended Hildebrand solubility approach (EHSA) was applied to evaluate the solubility of sulphanilamide, sulphapyridine and sulphamethizole in some propylene glycol + water mixtures at 298.15 K. Reported experimental solubility and some properties of fusion of this drug were used for the calculations. In particular, a good predictive character of EHSA has been found by using a regular polynomial in order five of the interaction parameter W as a function of the solubility parameter of solvent mixtures free of drug. Nevertheless, the predictive character of EHSA is the same as the one obtained by direct correlation between drug solubilities and the same descriptor of polarity of the co-solvent mixtures.
Table Of Contents: 1. Introduction, 2. Theoretical background, 3. Results and discussion, 4. Conclusions, 5. References
Program: Ingeniería Industrial
Headquarters: Neiva
Type: Artículo
CC Licence: Licencia CC
Citation: Zaira J. Cárdenas, Daniel M. Jiménez, Daniel R. Delgado, María Á. Peña & Fleming Martínez (2015) Extended Hildebrand solubility approach applied to some sulphonamides in propylene glycol + water mixtures, Physics and Chemistry of Liquids: An International Journal, 53:6, 763-775, DOI: 10.1080/00319104.2015.1048247
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Appears in Collections:Ingeniería Industrial

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