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Title: Overcoming research barriers in Chagas disease—designing effective implementation science
Author: Henao Martínez, Andrés
Colborn, Kathryn
Parra Henao, Gabriel
Issue Date: 23-Oct-2016
Keywords: Chagas
Implementation science
Health policies
Resume: Chagas disease remains a substantial source of morbidity and mortality in Latin America. The Pan American Health Organization estimates that 8 million people are infected in this part of the world ( Uruguay (2006). In the United States, which has high rates of Hispanic immigration, about 300,000 people are infected (Bern and Montgomery 2009; Kuehn 2015). Chagas transmission occurs mainly through contact with a triatomine or the Bkissing bug^ which carries the parasite, Trypanosoma cruzi. Transmission also occurs orally through food contamination with vector’s feces, vertically (perinatal), from organ donation and blood transfusion. Acute infections may be associated with fever or swelling around the site of the inoculation. Parasites can be detected in the blood for a few weeks following initial infection. If patients are not treated, they can develop severe medical complications, and this happens in about 20–30 % of those infected. These complications typically present as cardiac abnormalities and can lead to death (Morillo et al. 2015).
Abstract: Chagas disease is a complex tropical parasitic infection. It affects a significant portion of the population in Latin America, especially in areas of poverty and poor access to health care. It also affects immigrants in high-income countries who lack access to health care due to their legal status. Millions of people are at risk of contracting the disease, and approximately 30 % of chronically infected patients will develop cardiomyopathy. The cost of caring for patients that have been infected is substantial. Basic science research has introduced new concepts and knowledge for the parasite and vector biology as well as better understanding of the pathophysiology of the disease. These research findings nevertheless require effective and timely translation into clinical practice. Likewise, the design of new research projects should account for the multiple system–based barriers. Implementation science facilitates the applicability of research findings and identifies barriers to its execution. Creation of implementation science measures to reach and sustain research programs with greater potential to impact Chagas disease are lacking. This point of view proposes opportunities for implementation science in Chagas disease and strategies for researching effective interventions for preventing and treating the disease.
Program: Medicina
Headquarters: Santa Marta
Type: Artículo
CC Licence: Licencia CC
Citation: Henao Martínez, A., Colborn, K., Parra Henao, G. . (2016). Overcoming research barriers in Chagas disease—designing . Santa Marta: Universidad Cooperativa de Colombia
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