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|Title:||Haplotypes in CCR5-CCR2, CCL3 and CCL5 are associated with natural resistance to HIV-1 infection in a Colombian cohort.|
|Author:||Vega, Jorge A.|
Villegas Ospina, Simón
Aguilar Jiménez, Wbeimar
Rugeles, María T.
|Resume:||Introduction: Variants in genes encoding for HIV-1 co-receptors and their natural ligands have been individually associated to natural resistance to HIV-1 infection. However, the simultaneous presence of these variants has been poorly studied.|
|Abstract:||Results: Homozygosis of the human haplogroup (HH) E was absent in controls and frequent in cases, showing a tendency to susceptibility. The haplotypes C-C and T-T in CCL3 were associated with susceptibility (p’=0.016) and resistance (p’<0.0001) to HIV-1 infection, respectively. Finally, in multilocus analysis, the haplotype combinations formed by HHC in CCR5-CCR2, T-T in CCL3 and G-C in CCL5 were associated with resistance (p’=0.006). Conclusion: Our results suggest that specific combinations of variants in genes from the same signaling pathway can define an HIV-1 resistant phenotype. Despite our small sample size, our statistically significant associations suggest strong effects; however, these results should be further validated in larger cohorts.|
|Citation:||Vega, A. J., Villegas Ospina, S., Aguilar Jiménez, W., Rugeles, M. T., Bedoya, G., & Zapata, W. (2017). Haplotypes in CCR5-CCR2, CCL3 and CCL5 are associated with natural resistance to HIV-1 infection in a Colombian cohort. Biomédica, 37(2), 267-273. doi: http://dx.doi.org/10.7705/biomedica.v37i3.3237|
|Resource reference:||doi: http://dx.doi.org/10.7705/biomedica.v37i3.3237|
|Appears in Collections:||Medicina|
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