Electrocardiografía en modelos de investigación en ratas de laboratorio: monografía

Abstract

Electrocardiography along with other measures of vital signs in laboratory animals has become a gold standard in preclinical research, with rodents, mice and rats being the main biomodels used, this monograph is to collect, update and give references to In general and as a whole, the history of the development of the use of the rat and the ecg as research agents is exhibited, showing their obstacles to the current state of the art, the macro and microscopic morphology of the heart of this species is also exhibited, in terms of its functioning. The common basal rhythm in rats will be identified and arrhythmias will take into account those exposed by the Lambeth conventions, which are like AHA / ASA. In addition, it points out the existence of several techniques for recording the cardiac electrical potential, the best being the one that generates the least possible restriction, whether physical or pharmacological, causing physiological changes in the individual and therefore altering the results expected by the patient. researcher, who has led to a refinement of the Einthoven triangle and the search for new technological scenarios such as imaging, vectography, optical mapping or acoustic imaging for greater precision and use in isolated heart or in vitro. I will also mention the most representative pharmacological, surgical and genetic cardiovascular models, finally you will find webgraphs where you can find commercial and free useful information so that together with this document the bioterist who wants to electrocardiographically characterize his colony or the experimental researcher who uses the rat as a species and the data contained in the ecg as a variable or to take the heart rate as a vital sign of this animal.