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dc.contributor.advisorToledo Caceres, Edgar Hernando-
dc.creatorCano Villamizar, Hieffer-
dc.date.accessioned2022-04-22T16:03:37Z-
dc.date.available2022-04-22T16:03:37Z-
dc.date.issued2022-04-22-
dc.identifier.urihttp://hdl.handle.net/20.500.12494/44663-
dc.descriptionLa electrocardiografía junto con otras mediciones de signos vitales en animales de laboratorio se ha convertido en un estándar de oro en las investigaciones preclínicas, siendo los roedores el ratón y la rata los principales biomodelos utilizados, la presente monografía es recopilar, actualizar y da referencias a manera general y en conjunto de la historia del desarrollo del uso de la rata y el ecg como agentes de investigación mostrando sus obstáculos hasta el estado del arte presente, igualmente se exhibe morfología macro y microscópica del corazón de esta especie, en cuanto a su funcionamiento eléctrico se identificara el ritmo basal común en ratas y para las arritmias se tendrán en cuenta las expuestas por las convenciones Lambeth que son símiles AHA/ASA. Además señala la existencia de varias técnicas para el registro del potencial eléctrico cardiaco siendo la mejor que genere menor restricción posible, ya sea física o farmacológica puestas causan cambios fisiológicos en el individuo y por consiguiente alterando los resultados esperados por el investigador, el cual ha llevado a un perfeccionamiento del triángulo de Einthoven y a buscar nuevos panoramas tecnológicos como lo son la magnetografia, el vectografia, el mapeo óptico o la imagen acústica por su mayor precisión y uso en corazón aislado u in-vitro. También mencionare los modelos farmacológicos, quirúrgicos y genéticos cardiovascularmente más representativos, finalmente encontrará webgrafías donde podrá hallar información comercial y libre útil para que junto con el presente documento el bioterista que quiera caracterizar electrocardiográficamente su colonia o al investigador experimental que utilicen la rata como especie y los datos que contiene el ecg como variable o para toma del ritmo cardiaco como del signo vital de este animal.es
dc.description.abstractElectrocardiography along with other measures of vital signs in laboratory animals has become a gold standard in preclinical research, with rodents, mice and rats being the main biomodels used, this monograph is to collect, update and give references to In general and as a whole, the history of the development of the use of the rat and the ecg as research agents is exhibited, showing their obstacles to the current state of the art, the macro and microscopic morphology of the heart of this species is also exhibited, in terms of its functioning. The common basal rhythm in rats will be identified and arrhythmias will take into account those exposed by the Lambeth conventions, which are like AHA / ASA. In addition, it points out the existence of several techniques for recording the cardiac electrical potential, the best being the one that generates the least possible restriction, whether physical or pharmacological, causing physiological changes in the individual and therefore altering the results expected by the patient. researcher, who has led to a refinement of the Einthoven triangle and the search for new technological scenarios such as imaging, vectography, optical mapping or acoustic imaging for greater precision and use in isolated heart or in vitro. I will also mention the most representative pharmacological, surgical and genetic cardiovascular models, finally you will find webgraphs where you can find commercial and free useful information so that together with this document the bioterist who wants to electrocardiographically characterize his colony or the experimental researcher who uses the rat as a species and the data contained in the ecg as a variable or to take the heart rate as a vital sign of this animal.es
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dc.format.extent122 p.es
dc.publisherUniversidad Cooperativa de Colombia, Facultad de Ciencias de la Salud, Medicina Veterinaría y Zootecnia, Bucaramangaes
dc.subjectArritmiaes
dc.subjectCorazónes
dc.subjectExperimentales
dc.subjectRattus Norvegicuses
dc.subject.classificationTG 2022 MVZ 44663es
dc.subject.otherArrhythmiaes
dc.subject.otherHeartes
dc.subject.otherExperimentales
dc.subject.otherRattus Norvegicuses
dc.titleElectrocardiografía en modelos de investigación en ratas de laboratorio: monografíaes
dc.typeTrabajos de grado - Pregradoes
dc.rights.licenseAtribuciónes
dc.publisher.departmentBucaramangaes
dc.publisher.programMedicina veterinaria y zootecniaes
dc.description.tableOfContents1. Resumen. -- 2. Abstract. -- 3. Glosario. -- 4. Introducción. -- 5. Justificación. -- 6. Objetivos. -- 7. Marco teórico. -- 7.1. Historia de la investigación experimental en rata. -- 7.2. Historia del uso de la electrocardiografía en las investigaciones en roedores. -- 7.3. Estado del arte. -- 7.4. Conceptos y aspectos generales morfofisiológicos del corazón de la rata. -- 7.5. Énfasis macroscópico. -- 7.5.1. Corazón. -- 7.5.2. Cambio de forma durante el crecimiento. -- 7.5.3. Peso del corazón. -- 7.5.4. Válvulas cardíacas. -- 7.5.5. Sistema de conducción. -- 7.5.6. Grandes vasos. -- 7.5.7. Vasculatura coronaria. -- 7.6. Énfasis microscópico. -- 7.6.1. Miocardio. -- 7.6.2. Orientación del miocito. -- 7.6.3. Composición celular. -- 7.6.4. Dimensiones de los miocitos. -- 7.6.5. Cambios estructurales del miocito durante el crecimiento. -- 7.6.6. Miocardio auricular. -- 7.6.7. Endocardio, epicardio y saco pericárdico. -- 7.6.8. Válvulas cardiacas. -- 7.6.9. Los grandes vasos y vasculatura cardiaca. -- 7.7. Sistema de conducción. -- 7.8. El electrocardiograma: componentes e interpretacion. -- 7.8.1. Frecuencia cardíaca e intervalo RR. -- 7.8.2. La onda P. -- 7.8.3. Intervalo PR. -- 7.8.4. Complejo QRS. -- 7.8.5. Segmento ST. -- 7.8.6. Onda T. -- 7.8.7. Intervalo QT. -- 7.8.8. Intervalo QT corregido. -- 7.8.9. La variabilidad de la frecuencia cardíaca (VFC). -- 7.8.10. El efecto de la anestesia en el ECG. -- 7.9. Arritmias. -- 7.9.1. Arritmias ventriculares. -- 7.9.2. Arritmias supra ventriculares. -- 7.9.3. Ejemplos. -- 7.10. Técnicas de registro del ECG. -- 7.10.1. ECG de superficie. -- 7.10.2. Registro de ecg con sistema de telemetría. -- 7.10.3. Técnicas de registro de la actividad electrica distintas a las convencionales. -- 7.11. Modelos experimentales y genéticos. -- 7.11.1. Modelos experimentales. -- 7.11.2. Modelos génicos de ratas. -- 7.11.3. Modelos transgénicos. -- 7.11.4. Modelos de corazón aislado. -- 7.12. Herramientas y base de datos sobre las ratas. -- 8. Conclusiones. -- 9. Alcances. -- 10. Referencias.es
dc.creator.mailhieffer.canov@campusucc.edu.coes
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