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https://repository.ucc.edu.co/handle/20.500.12494/42877
Title: | Characterization of the venom of C. d. cumanesis of Colombia: Proteomic analysis and antivenomic study |
Author: | Quintana Castillo, Juan Carlos Vargas Muñoz, Leidy Johana Segura C. Estrada-Gómez S. Bueno-Sánchez J.C. Alarcón J.C. |
Email autor: | leidy.vargasmu@campusucc.edu.co |
Issue Date: | 2018 |
Keywords: | crotamine crotoxin disintegrin lectin serine proteinase snake venom reptilian protein snake venom venom antiserum amino acid sequence Article Crotalus Crotalus durissus cumanensis electrophoresis electrospray mass spectrometry nonhuman oxidation protein analysis protein isolation proteomics reversed phase high performance liquid chromatography Western blotting animal chemistry Colombia Crotalus immunology proteomics Animals Antivenins Colombia Crotalid Venoms Crotalus Proteomics Reptilian Proteins |
Abstract: | The Colombian rattlesnake Crotalus durissus cumanensis is distributed in three geographic zones of the country: the Atlantic Coast, the upper valley of the Magdalena River, and the eastern plains of the Colombian Orinoquía. Its venom induces neurological symptoms, such as eyelid ptosis, myasthenic facies, and paralysis of the respiratory muscles, which can lead to death. Identification and analysis of C. d. cumanensis showed nine groups of proteins responsible for the neurotoxic effect, of which the crotoxin complex was the most abundant (64.71%). Immunorecognition tests of C. d. cumanensis showed that the use of a commercial antivenom manufactured in Mexico resulted in immunoreactivity. © 2018 by the authors. |
Publisher: | MDPI AG |
metadata.dc.type: | Artículo |
Citation: | Quintana JC,Johanavargas L,Segura C,Estrada S,Bueno JC,Alarcón JC. Characterization of the venom of C. d. cumanesis of Colombia: Proteomic analysis and antivenomic study. Toxins (Basel). 2018. 10. (2):p. 1-12. . |
Other Identifiers: | https://doi.org/10.6018/eglobal.16.2.255821 https://www.tandfonline.com/doi/abs/10.1080/00319104.2011.584311 |
Appears in Collections: | Artículos Científicos |
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