Please use this identifier to cite or link to this item: https://repository.ucc.edu.co/handle/20.500.12494/42877
Title: Characterization of the venom of C. d. cumanesis of Colombia: Proteomic analysis and antivenomic study
Author: Quintana Castillo, Juan Carlos
Vargas Muñoz, Leidy Johana
Segura C.
Estrada-Gómez S.
Bueno-Sánchez J.C.
Alarcón J.C.
Email autor: leidy.vargasmu@campusucc.edu.co
Issue Date: 2018
Keywords: crotamine
crotoxin
disintegrin
lectin
serine proteinase
snake venom
reptilian protein
snake venom
venom antiserum
amino acid sequence
Article
Crotalus
Crotalus durissus cumanensis
electrophoresis
electrospray mass spectrometry
nonhuman
oxidation
protein analysis
protein isolation
proteomics
reversed phase high performance liquid chromatography
Western blotting
animal
chemistry
Colombia
Crotalus
immunology
proteomics
Animals
Antivenins
Colombia
Crotalid Venoms
Crotalus
Proteomics
Reptilian Proteins
Abstract: The Colombian rattlesnake Crotalus durissus cumanensis is distributed in three geographic zones of the country: the Atlantic Coast, the upper valley of the Magdalena River, and the eastern plains of the Colombian Orinoquía. Its venom induces neurological symptoms, such as eyelid ptosis, myasthenic facies, and paralysis of the respiratory muscles, which can lead to death. Identification and analysis of C. d. cumanensis showed nine groups of proteins responsible for the neurotoxic effect, of which the crotoxin complex was the most abundant (64.71%). Immunorecognition tests of C. d. cumanensis showed that the use of a commercial antivenom manufactured in Mexico resulted in immunoreactivity. © 2018 by the authors.
Publisher: MDPI AG
metadata.dc.type: Artículo
Citation: Quintana JC,Johanavargas L,Segura C,Estrada S,Bueno JC,Alarcón JC. Characterization of the venom of C. d. cumanesis of Colombia: Proteomic analysis and antivenomic study. Toxins (Basel). 2018. 10. (2):p. 1-12. .
Other Identifiers: https://doi.org/10.6018/eglobal.16.2.255821
https://www.tandfonline.com/doi/abs/10.1080/00319104.2011.584311
Appears in Collections:Artículos Científicos

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