Please use this identifier to cite or link to this item: https://repository.ucc.edu.co/handle/20.500.12494/41929
Title: Vitamin D treatment of peripheral blood mononuclear cells modulated immune activation and reduced susceptibility to HIV-1 infection of CD4+ T lymphocytes.
Author: Gonzalez, Sandra M
Aguilar-Jimenez, Wbeimar
Trujillo-Gil, Edison
Zapata Builes, Wildeman
Su, Ruey-Chyi
Ball, T Blake
Rugeles, Maria T
Email autor: wildeman.zapatab@campusucc.edu.co
Issue Date: 2019
Keywords: ADP ribosyl cyclase/cyclic ADP ribose hydrolase 1
apolipoprotein B messenger RNA editing enzyme catalytic polypeptide 3G
calcitriol
cathelicidin
granzyme
HLA DR antigen
immunoglobulin enhancer binding protein
interleukin 2
macrophage inflammatory protein 1beta
virus receptor
antimicrobial cationic peptide
APOBEC3G protein
human
apolipoprotein B messenger RNA editing enzyme catalytic polypeptide 3G
calcitriol
CAP18 lipopolysaccharide-binding protein
HLA DR antigen
vitamin
APOBEC3G gene
Article
CAMP gene
Canada
CD4+ T lymphocyte
cell cloning
cohort analysis
Colombia
controlled study
drug effect
female
human
human cell
Human immunodeficiency virus infection
immunomodulation
in vitro study
infection sensitivity
lymphocyte activation
lymphocyte function
male
peripheral blood mononuclear cell
protein expression
serodiagnosis
T lymphocyte subpopulation
viral tropism
virus gene
virus strain
blood
CD4+ T lymphocyte
cell culture
Human immunodeficie
Abstract: Mucosal immune activation, in the context of sexual transmission of HIV-1 infection, is crucial, as the increased presence of activated T cells enhance susceptibility to infection. In this regard, it has been proposed that immunomodulatory compounds capable of modulating immune activation, such as Vitamin D (VitD) may reduce HIV-1 transmission and might be used as a safe and cost-effective strategy for prevention. Considering this, we examined the in vitro effect of the treatment of peripheral blood mononuclear cells (PBMCs) with the active form of VitD, calcitriol, on cellular activation, function and susceptibility of CD4+ T cells to HIV-1 infection.
Publisher: Public Library of Science
metadata.dc.type: Artículo
Citation: Gonzalez SM,Aguilar W,Trujillo E,Zapata W,Su RC,Ball TB,Rugeles MT. Vitamin D treatment of peripheral blood mononuclear cells modulated immune activation and reduced susceptibility to HIV-1 infection of CD4+ T lymphocytes. PLoS One. 2019. 14. (9):e0222878. .
Other Identifiers: https://doi.org/10.18041/1794-4953/avances.2.256
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85029379594&doi=10.1155%2f2017%2f1090534&partnerID=40&md5=cdaf6480d676a3c1077735c6ae9286b0
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