Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12494/41838
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Title: Molecular characterization of dengue virus reveals regional diversification of serotype 2 in Colombia
Author: Laiton-Donato K.
Alvarez D.A.
Peláez-Carvajal D.
Mercado M.
Ajami N.J.
Bosch I.
Usme Ciro, Jose Aldemar
Email autor: jose.usmec@campusucc.edu.co
Issue Date: 2019
Keywords: adolescent
adult
Article
child
clinical article
Colombia
Dengue virus
envelope gene
female
gene sequence
genetic variability
genotype
geography
human
male
middle aged
nonhuman
nucleotide sequence
phylogeny
retrospective study
severe dengue
virus characterization
virus gene
virus isolation
biobank
blood
dengue
Dengue virus
genetic variation
genetics
genotype
high throughput sequencing
preschool child
serotype
virology
young adult
virus envelope protein
virus RNA
Adolescent
Adult
Biological Specimen Banks
Child
Child
Preschool
Colombia
Dengue
Dengue Virus
Female
Genetic Variation
Genotype
High-Throughput Nucleotide Sequencing
Humans
Male
Middle Aged
Phylogeny
Retrospective Studies
RNA
Viral
Serogroup
Viral Envelope Proteins
Young Adult
Abstract: Dengue is hyperendemic in Colombia, where a cyclic behavior of serotype replacement leading to periodic epidemics has been observed for decades. This level of endemicity favors accumulation of dengue virus genetic diversity and could be linked to disease outcome. To assess the genetic diversity of dengue virus type 2 in Colombia, we sequenced the envelope gene of 24 virus isolates from acute cases of dengue or severe dengue fever during the period 2013-2016. The phylogenetic analysis revealed the circulation of the Asian-American genotype of dengue virus type 2 in Colombia during that period, the intra-genotype variability leading to divergence in two recently circulating lineages with differential geographic distribution, as well as the presence of nonsynonymous substitutions accompanying their emergence and diversification. © 2019 The Author(s).
Type: Artículo
Citation: Laiton K,Alvarez DA,Peláez D,Mercado M,Ajami NJ,Bosch I,Usme JA. Molecular characterization of dengue virus reveals regional diversification of serotype 2 in Colombia. VIROL J. 2019. 16. (1):p. 62-62. .
Other Identifiers: https://doi.org/10.16925/ra.v17i31.1096
Appears in Collections:Artículos Científicos

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