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Title: A novel approach to create an antibacterial surface using titanium dioxide and a combination of dip-pen nanolithography and soft lithography
Author: Arango Santander, Santiago
Pelaez Vargas, Alejandro
Da Cunha Freitas, Sidonio Ricardo
García González, Claudia Patricia
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Issue Date: 2018
Keywords: antiinfective agent
biocompatible coated material
titanium dioxide
atomic force microscopy
bacterium adherence
drug effect
microbial viability
Streptococcus mutans
surface property
Anti-Bacterial Agents
Bacterial Adhesion
Coated Materials
Microbial Viability
Atomic Force
X-Ray Emission
Streptococcus mutans
Surface Properties
Abstract: Soft lithography and Dip-Pen Nanolithography (DPN) are techniques that have been used to modify the surface of biomaterials. Modified surfaces play a role in reducing bacterial adhesion and biofilm formation. Also, titanium dioxide has been reported as an antibacterial substance due to its photocatalytic effect. This work aimed at creating patterns on model surfaces using DPN and soft lithography combined with titanium dioxide to create functional antibacterial micropatterned surfaces, which were tested against Streptococcus mutans. DPN was used to create a master pattern onto a model surface and microstamping was performed to duplicate and transfer such patterns to medical-grade stainless steel 316L using a suspension of TiO2. Modified SS316L plates were subjected to UVA black light as photocatalytic activator. Patterns were characterized by atomic force microscopy and biologically evaluated using S. mutans. A significant reduction of up to 60% in bacterial adhesion to TiO2 -coated and -micropatterned surfaces was observed. Moreover, both TiO2 surfaces reduced the viability of adhered bacteria after UV exposure. TiO2 micropatterned demonstrated a synergic effect between physical and chemical modification against S. mutans. This dual effect was enhanced by increasing TiO2 concentration. This novel approach may be a promising alternative to reduce bacterial adhesion to surfaces. © 2018, The Author(s).
Publisher: Nature Publishing Group
metadata.dc.type: Artículo
Citation: Arango S,Pelaez A,Freitas SC,García C. A novel approach to create an antibacterial surface using titanium dioxide and a combination of dip-pen nanolithography and soft lithography. Sci Rep. 2018. 8. (1):p. 15818-15818. .
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Appears in Collections:Artículos Científicos

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