Please use this identifier to cite or link to this item: https://repository.ucc.edu.co/handle/20.500.12494/41668
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dc.creatorArango Santander, Santiago-
dc.creatorPelaez Vargas, Alejandro-
dc.creatorDa Cunha Freitas, Sidonio Ricardo-
dc.creatorGarcía González, Claudia Patricia-
dc.date.accessioned2021-12-16T22:15:41Z-
dc.date.available2021-12-16T22:15:41Z-
dc.date.issued2018-
dc.identifierhttps://doi.org/10.1371/journal.pone.0131139-
dc.identifierhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85047801014&doi=10.17843%2frpmesp.2018.351.3568&partnerID=40&md5=61166e074cf91df0e8870ace5c72294c-
dc.identifier.issn20452322es
dc.identifier.urihttp://hdl.handle.net/20.500.12494/41668-
dc.description.abstractSoft lithography and Dip-Pen Nanolithography (DPN) are techniques that have been used to modify the surface of biomaterials. Modified surfaces play a role in reducing bacterial adhesion and biofilm formation. Also, titanium dioxide has been reported as an antibacterial substance due to its photocatalytic effect. This work aimed at creating patterns on model surfaces using DPN and soft lithography combined with titanium dioxide to create functional antibacterial micropatterned surfaces, which were tested against Streptococcus mutans. DPN was used to create a master pattern onto a model surface and microstamping was performed to duplicate and transfer such patterns to medical-grade stainless steel 316L using a suspension of TiO2. Modified SS316L plates were subjected to UVA black light as photocatalytic activator. Patterns were characterized by atomic force microscopy and biologically evaluated using S. mutans. A significant reduction of up to 60% in bacterial adhesion to TiO2 -coated and -micropatterned surfaces was observed. Moreover, both TiO2 surfaces reduced the viability of adhered bacteria after UV exposure. TiO2 micropatterned demonstrated a synergic effect between physical and chemical modification against S. mutans. This dual effect was enhanced by increasing TiO2 concentration. This novel approach may be a promising alternative to reduce bacterial adhesion to surfaces. © 2018, The Author(s).es
dc.description.provenanceMade available in DSpace on 2021-12-16T22:15:41Z (GMT). No. of bitstreams: 0 Previous issue date: 2018en
dc.format.extent15818-15818es
dc.publisherNature Publishing Groupes
dc.relation.ispartofSCI REP-UKes
dc.subjectantiinfective agentes
dc.subjectbaysilones
dc.subjectbiocompatible coated materiales
dc.subjectdimeticonees
dc.subjecttitaniumes
dc.subjecttitanium dioxidees
dc.subjectwateres
dc.subjectatomic force microscopyes
dc.subjectbacterium adherencees
dc.subjectchemistryes
dc.subjectdrug effectes
dc.subjectmicrobial viabilityes
dc.subjectnanotechnologyes
dc.subjectprintinges
dc.subjectprocedureses
dc.subjectspectroscopyes
dc.subjectStreptococcus mutanses
dc.subjectsurface propertyes
dc.subjectultrastructurees
dc.subjectAnti-Bacterial Agentses
dc.subjectBacterial Adhesiones
dc.subjectCoated Materialses
dc.subjectBiocompatiblees
dc.subjectDimethylpolysiloxaneses
dc.subjectMicrobial Viabilityes
dc.subjectMicroscopyes
dc.subjectAtomic Forcees
dc.subjectNanotechnologyes
dc.subjectPrintinges
dc.subjectSpectrometryes
dc.subjectX-Ray Emissiones
dc.subjectStreptococcus mutanses
dc.subjectSurface Propertieses
dc.subjectTitaniumes
dc.subjectWateres
dc.titleA novel approach to create an antibacterial surface using titanium dioxide and a combination of dip-pen nanolithography and soft lithographyes
dc.typeArtículo-
dc.creator.mailalejandro.pelaezv@campusucc.edu.coes
dc.identifier.bibliographicCitationArango S,Pelaez A,Freitas SC,García C. A novel approach to create an antibacterial surface using titanium dioxide and a combination of dip-pen nanolithography and soft lithography. Sci Rep. 2018. 8. (1):p. 15818-15818. .es
dc.rights.accessRightsDesconocidoes
dc.description.orcid0000-0001-7582-2760es
Appears in Collections:Artículos Científicos

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