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Title: Applications of the European Parkinson's Disease Association sponsored Parkinson's Disease Composite Scale (PDCS).
Author: Balestrino, Roberta
Hurtado Gonzalez, Carlos Alberto
Stocchi, Fabrizio
Radicati, Fabiana Giada
Chaudhuri, K Ray
Rodriguez-Blazquez, Carmen
Martinez-Martin, Pablo
Pdcs European Study Group
Adarmes, Astrid D
Méndez-Del-Barrio, Carlota
Ariadne, Vakirli
Aschermann, Zsuzsanna
Juhász, Annamária
Harmat, Márk
Bostantjopoulou, Sevasti
Corbo, Massimo
Grassi, Andrea
Dellaporta, Dionysia
Falup-Pecurariu, Cristian
Diaconu, Stefania
Giagkou, Nikolaos
Guekht, Alla
Popov, Georgy
Gurevich, Tanya
Johansson, Anders
Sundgren, Mathias
Kefalopoulou, Zinovia
Ellul, John
Kostic, Vladimir S
Kovacs, Norbert
Marti, Maria J
Planelles, Lluis
Migirov-Sanderovich, Angel
Ezra, Adi
Minar, Michal
Mir, Pablo
Necpal, Jan
Popovici, Maria
Simitsi, Athima
Stefanis, Leonidas
Simu, Mihaela
Rosca, Cecilia
Skorvanek, Matej
Stefani, Alessandro
Cerroni, Rocco
Stamelou, Maria
Tsolaki, Magda
Vuletic, Vladimira
Katsarou, Zoe
Email autor:
Issue Date: 2019
Keywords: Epidemiology
Parkinson's disease
Abstract: This study was addressed to determine the presence of Parkinson disease (PD) manifestations, their distribution according to motor subtypes, and the relationships with health-related quality of life (QoL) using the recently validated European Parkinson's Disease Association sponsored Parkinson's Disease Composite Scale (PDCS). Frequency of symptoms was determined by the scores of items (present if >0). Using ROC analysis and Youden method, MDS-UPDRS motor subtypes were projected on the PDCS to achieve a comparable classification based on the PDCS scores. The same method was used to estimate severity levels from other measures in the study. The association between the PDCS and QoL (PDQ-39) was analyzed by correlation and multiple linear regression. The sample consisted of 776 PD patients. We found that the frequency of PD manifestations with PDCS and MDS-UPDRS were overlapping, the average difference between scales being 5.5% only. Using the MDS-UPDRS subtyping, 215 patients (27.7%) were assigned as Tremor Dominant (TD), 60 (7.7%) Indeterminate, and 501 (64.6%) Postural Instability and Gait Difficulty (PIGD) in this cohort. With this classification as criterion, the analogous PDCS-based ratio provided these cut-off values: TD subtype, =1.06; Indeterminate, <1.06 but >0.65; and PIGD, <0.65. The agreement between the two scales on this classification was substantial (87.6%; kappa = 0.69). PDCS total score cut-offs for PD severity were: 23/24 for mild/moderate and 41/42 for moderate/severe. Moderate to high correlations ( r = 0.35-0.80) between PDCS and PDQ-39 were obtained, and the four PDCS domains showed a significant independent influence on QoL. The conclusions are: (1) the PDCS assessed the frequency of PD symptoms analogous to the MDS-UPDRS; (2) motor subtypes and severity levels can be determined with the PDCS; (3) a significant association between PDCS and QoL scores exists.
Type: Artículo
Citation: Balestrino R,Hurtado CA,Stocchi F,Radicati FG,Chaudhuri KR,Rodriguez C,Martinez P,European Study Group PDCS,Adarmes AD,Méndez C,Ariadne V,Aschermann Z,Juhász A,Harmat M,Bostantjopoulou S,Corbo M,Grassi A,Dellaporta D,Falup C,Diaconu S,Giagkou N,Guekht A,Popov G,Gurevich T,Johansson A,Sundgren M,Kefalopoulou Z,Ellul J,Kostic VS,Kovacs N,Marti MJ,Planelles L,Migirov A,Ezra A,Minar M,Mir P,Necpal J,Popovici M,Simitsi A,Stefanis L,Simu M,Rosca C,Skorvanek M,Stefani A,Cerroni R,Stamelou M,Tsolaki M,Vuletic V,Katsarou Z. Applications of the European Parkinson's Disease Association sponsored Parkinson's Disease Composite Scale (PDCS). NPJ Parkinsons Dis. 2019. 5. (1):p. 26-26. .
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