Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12494/41489
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Title: Assessment of endocrine disruptor effects of levonorgestrel and its photoproducts: Environmental implications of released fractions after their photocatalytic removal
Author: Narváez J.F.
Grant H.
Gil V.C.
Porras J.
Bueno Sanchez J.C.
Ocampo Duque L.F.
Sossa R.R.
Quintana Castillo, Juan Carlos
Email autor: juan.quintanac@campusucc.edu.co
Issue Date: 2019
Keywords: Cell culture
Effluents
Wastewater treatment
Cell lines
Endocrine disruptor
Levonorgestrel
Photo catalytic degradation
Photo-catalytic removal
Risk assessment
chorionic gonadotropin beta subunit
endocrine disruptor
levonorgestrel
assessment method
catalysis
cell component
chemical compound
degradation
effluent
endocrine disruptor
excretion
hormone
pollutant removal
pregnancy
reproduction
risk assessment
toxicity
wastewater
wastewater treatment plant
aquatic species
Article
BeWo cell line
cell proliferation
cell viability
controlled study
effluent
hormone synthesis
mineralization
photocatalysis
photodegradation
photolysis
reproductive toxicity
risk assessment
sunlight
trophoblast
ultraviolet C radiation
waste water management
Abstract: The presence of levonorgestrel (LNG) in water bodies via direct discharge and human excretion has been reported worldwide, but its effects on the reproduction of aquatic species and humans are still unknown. Owing to its recalcitrant properties, LNG is not completely removed during wastewater treatment plants, and many species may be exposed to low traces of this compound from discharged effluents. Thus, in this study, a photocatalytic process for removing LNG along with screening of endocrine disruptor effects for risk assessment was applied. Although the removal rate of LNG by ultraviolet C (UV-C) radiation was >90%, reproductive toxicity testing using the BeWo cell line exposed to LNG and its degraded fraction showed the reduced production of basal human chorionic gonadotropin hormone (ß-hCG) by more than 73%, from 8.90 mIU mL-1 to <2.39 mIU mL-1, with both LNG and the degraded fraction. ß-hCG hormone has been implicated in the viability of trophoblastic cells during the first trimester of pregnancy; therefore, degraded fractions and waterborne LNG may affect reproduction in some aquatic species and humans with low level of exposure. © 2019
Type: Artículo
Citation: Narváez JF,Grant H,Gil VC,Porras J,Bueno JC,Ocampo LF,Sossa RR,Quintana JC. Assessment of endocrine disruptor effects of levonorgestrel and its photoproducts: Environmental implications of released fractions after their photocatalytic removal. J Hazard Mater. 2019. 371. p. 273-279. .
Other Identifiers: https://doi.org/10.1016/j.rcp.2016.04.002
Appears in Collections:Artículos Científicos

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