Publicación: Asociación entre la caries dental y las variantes genéticas en el gen de la enamelina
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Introduction: The research topic is dental caries, which is described as a chronic disease, not contagious, mediated by bacteria and frequent in humans. It is characterized by causing permanent damage to the surface of the teeth, causing holes or openings in them. This pathology affects millions of people throughout the world and can lead to death in children and adults. Objective: to describe the association between dental caries and genetic variants in the enamelin gene through a literature search between 2015 and 2020. Materials and method: corresponds to a narrative monograph developed from a narrative review protocol , whose primary language was English, based on the MeSH Medical Subject Headings vocabulary. A search was also carried out in Spanish with fewer results. The search protocol generated 579 results for Ovid Medline, 842 for Proquest Health & Medical Collection, 25 for Sciencedirect, 23 Proquest and 331 academic Google, from which five studies associated with the topic and proposed objectives were chosen. Results: 9 variants or polymorphisms were found. Conclusions: it was evidenced that the Enamelin gene plays an important role in the development of dental enamel in relation to the variant rs12640848 and rs7671281 in the etiology of caries. The rs7671281, rs12640848 and C2452T polymorphisms act as a risk factor for caries production.Keywords: Dental Caries, Genetic Polymorphism, Tooth Enamel.