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Title: Phylogenomic analysis of two co-circulating canine distemper virus lineages in Colombia
Author: Duque Valencia, July
Diaz, Francisco
Ruiz-SAenz, Julian
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Issue Date: 1-Jan-2020
Keywords: Phylogenomics
Lineages co-circulation
Resume: Canine distemper virus (CDV) is considered a reemerging disease-causing agent in domestic dogs because it presents high divergence among circulating strains worldwide. In Colombia, the South America-3 and South America/North America-4 lineages co-circulate in domestic dogs, both in the Medellin metropolitan area. In this paper, two full CDV genomes from each viral lineage circulating in Medellin were sequenced; we explored the phylogenetic relationship with the available genome sequences; we described the presence of CDV mutations in the South America-3 and South America/North America-4 lineages associated with adaptation to human cells and a crossing of the species barrier and pathogenicity; and we established the evolutionary rates and time of the closest common ancestor for each gene and characterized the presentation of multiple genomic sites by positive selection
Program: Medicina veterinaria y zootecnia
Headquarters: Bucaramanga
Type: Artículos Científicos
Citation: Duque-Valencia J, Diaz FJ, Ruiz-Saenz J. Phylogenomic Analysis of Two Co-Circulating Canine Distemper Virus Lineages in Colombia. Pathogens. 2020; 9(1):26.
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Appears in Collections:Medicina Veterinaria Zootecnia

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