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Title: Solubility of sulfadiazine in (ethylene glycol + water) mixtures: Measurement, correlation, thermodynamics and preferential solvation
Author: Cruz-González, Ana María
Vargas-Santana, Martha Sofía
Ortiz, Claudia Patricia
Cerquera, Néstor Enrique
Delgado, Daniel Ricardo
Martínez, Fleming
Jouyban, Abolghasem
Acree Jr, William E.
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Issue Date: 1-Feb-2021
Keywords: Sulfadiazina
{etilenglicol (1) + agua (2)} mezclas
Modelo Jouyban-Acree
Solvatación preferencial
Resume: Se informa la solubilidad en equilibrio de la sulfadiazina (SD) en mezclas de {etilenglicol (EG) (1) + agua (2)} a temperaturas de (278,15 a 318,15) K. La solubilidad de la fracción molar de SD ( x 3 ) aumenta con el aumento de temperatura y también aumenta con el aumento de la proporción de EG. Varía de 4.81 × 10 −6 en agua pura a 5.32 × 10 −4en EG puro a 298,15 K. El comportamiento de solubilidad se correlacionó con el modelo log-lineal extendido de Yalkowsky, el modelo de Jouyban-Acree y el modelo de Jouyban-Acree-van't Hoff y las desviaciones porcentuales medias obtenidas son 43,6%, 7,0% y 7,1%, respectivamente. A partir de la variación de la solubilidad con la temperatura, se realizó el análisis termodinámico aparente de disolución y mezcla en todas las mezclas y disolventes puros. Basado en las integrales inversas de Kirkwood-Buff (IKBI) se observa que SD se solvata preferentemente con agua en mezclas ricas en agua (0,00 < x 1 <0,24) pero preferentemente se solvata con EG en el intervalo (0,24 < x 1 <1,00).
Abstract: The equilibrium solubility of sulfadiazine (SD) in {ethylene glycol (EG) (1) + water (2)} mixtures at temperatures from (278.15 to 318.15) K is reported. Mole fraction solubility of SD (x3) increases with temperature arising and also increases with the EG proportion increasing. It varies from 4.81 × 10−6 in neat water to 5.32 × 10−4 in neat EG at 298.15 K. Solubility behavior was correlated by the extended log-linear model of Yalkowsky, the Jouyban-Acree model, and Jouyban-Acree-van't Hoff model and the obtained mean percentage deviations are 43.6%, 7.0% and 7.1%, respectively. From the variation of solubility with temperature the apparent thermodynamic analysis of dissolution and mixing was performed in all the mixtures and neat solvents. Based on the inverse Kirkwood-Buff integrals (IKBI) is observed that SD is preferentially solvated by water in water-rich mixtures (0.00 < x1 < 0.24) but preferentially solvated by EG in the interval (0.24 < x1 < 1.00).
Table Of Contents: Highlights. -- Abstract. -- Keywords. -- 1. Introduction. -- 2. Experimental. -- 3. Results and discussion. -- 4. Conclusions. -- Declaration of Competing Interest. -- Acknowledgements. -- References.
Program: Ingeniería Industrial
Headquarters: Neiva
Type: Artículo
Citation: Cruz et al. Solubility of sulfadiazine in (ethylene glycol + water) mixtures: Measurement, correlation, thermodynamics and preferential solvation, Journal of Molecular Liquids Volume 323, 1 February 2021, 115058
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