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dc.coverage.temporal38es
dc.creatorPelaez-Carvajal, Dioselina-
dc.creatorForero, Nidia J.-
dc.creatorEscalante-Mora, Martha-
dc.creatorLaiton-Donato, Katherine-
dc.creatorUsme-Ciro, Jose A.-
dc.date.accessioned2021-01-21T00:45:44Z-
dc.date.available2021-01-21T00:45:44Z-
dc.date.issued2018-08-01-
dc.identifier.issn2590-7379es
dc.identifier.uri10.7705/biomedica.v38i3.3871es
dc.identifier.urihttp://hdl.handle.net/20.500.12494/32708-
dc.descriptionIntroducción. Se estima que 240 millones de personas en el mundo tienen infección crónica con el virus de la hepatitis B (HBV). En Colombia, la endemia es variable y circulan diferentes genotipos virales. Las mutaciones a lo largo del genoma se han asociado con resistencia antiviral, el escape ante la reacción de anticuerpos neutralizadores tras la vacunación o a la infección natural, la infección oculta y la progresión a carcinoma hepatocelular. Objetivo. Identificar los genotipos y las mutaciones presentes en la región codificante del antígeno de superficie (S) y del dominio de la transcriptasa inversa (reverse transcriptase, RT) de la polimerasa del HBV en muestras de suero remitidas al Instituto Nacional de Salud de Colombia para el diagnóstico de hepatitis B, entre el 2002 y el 2014. Materiales y métodos. En 495 muestras de suero positivas para el antígeno de superficie de la hepatitis B (HBsAg) se buscó el ADN viral, se amplificó y secuenció un fragmento de 1.591 nucleótidos y, posteriormente, se hizo el análisis filogenético correspondiente. Resultados. En 66 de las muestras se logró detectar el genoma viral y 28 de ellas se secuenciaron exitosamente. El análisis filogenético permitió identificar los genotipos y subgenotipos F3 y A2. Una muestra presentó simultáneamente las sustituciones de resistencia L180M y M204V, otra presentó la sustitución I169L y en una se identificó la mutación P120Q, previamente asociada con variantes de escape. Dos muestras presentaron una deleción de 105 nucleótidos en la región preS1-preS2. Conclusiones. Se corroboró la circulación en Colombia de los genotipos y subgenotipos F3 y A2, así como la presencia de mutaciones de resistencia y escape. El presente estudio constituye un aporte a la epidemiologia molecular del HBV en Colombia.es
dc.format.extent14es
dc.publisherUniversidad Cooperativa de Colombia, Facultad de Ciencias de la Salud, Medicina, Santa Martaes
dc.relation.ispartofBiomedicaes
dc.relation.isversionofhttps://revistabiomedica.org/index.php/biomedica/article/view/3871es
dc.subjectVirus de la hepatitis Bes
dc.subjectGenotipoes
dc.subjectADN Polimerasa dirigida por ARNes
dc.subjectMutaciónes
dc.subject.otherHepatitis B viruses
dc.subject.otherGenotypees
dc.subject.otherMutationes
dc.subject.otherRNA Dependent DNA Polymerasees
dc.titleVariabilidad genética en regiones codificantes del antígeno de superficie y dominio transcriptasa inversa de la polimerasa del virus de la hepatitis B, Colombia, 2002-2014es
dc.typeArtículoes
dc.rights.licenseAtribuciónes
dc.publisher.departmentSanta Martaes
dc.publisher.programMedicinaes
dc.creator.mailjose.usmec@campusucc.edu.coes
dc.identifier.bibliographicCitationPeláez-Carvajal, D., Forero, N. J., Escalante-Mora, M., Laiton-Donato, K., & Usme-Ciro, J. A. (2018). Variabilidad genética en regiones codificantes del antígeno de superficie y el dominio de la transcriptasa inversa de la polimerasa del virus de la hepatitis B, Colombia, 2002-2014. Biomédica, 38, 37–50.es
dc.rights.accessRightsopenAccesses
dc.publisher.editorDr. Luis Alberto Gomezes
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