Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12494/28267
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Title: Toll-like receptors as a therapeutic target in cancer, infections and inflammatory diseases
Author: Flórez-Álvarez, Lizdany
Ruiz-Perez, Lanie
Taborda, Natalia
Hernandez, Juan C
Email autor: juanc.hernandezl@campusucc.edu.co
metadata.dc.description.cvlac: https://scienti.colciencias.gov.co/cvlac/visualizador/generarCurriculoCv.do?cod_rh=0000283088
Issue Date: 2-Apr-2020
Keywords: Toll-like receptors
cancer
vaccines
inflammation
infectious diseases
immune modulators
Resume: Toll-like receptors (TLRs) are widely expressed pattern recognition receptors that bind to conserved molecular patterns expressed by pathogens and damaged cells. After recognition, activated TLRs induce the expression of various proinflammatory and antiviral molecules. Thus, TLRs are potential targets for treatment strategies aimed at boosting the adaptive immune response to vaccines, controlling infections, enhancing immune responses during tumor treatment and attenuating immune responses in inflammatory disorders. This Special Report examines the potential of TLRs as targets for the treatment of cancer, infections and inflammatory diseases. Here, we make a particular emphasis on molecules capable of modulating TLRs and their therapeutic applications.
Abstract: Toll-like receptors (TLRs) are widely expressed pattern recognition receptors that bind to conserved molecular patterns expressed by pathogens and damaged cells. After recognition, activated TLRs induce the expression of various proinflammatory and antiviral molecules. Thus, TLRs are potential targets for treatment strategies aimed at boosting the adaptive immune response to vaccines, controlling infections, enhancing immune responses during tumor treatment and attenuating immune responses in inflammatory disorders. This Special Report examines the potential of TLRs as targets for the treatment of cancer, infections and inflammatory diseases. Here, we make a particular emphasis on molecules capable of modulating TLRs and their therapeutic applications.
Program: Medicina
Headquarters: Medellín
Type: Artículo
Citation: Flórez-Álvarez, F., Ruiz-Perez, L., Taborda, N. y Hernandez, J. C. (2020). Toll-like receptors as a therapeutic target in cancer, infections and inflammatory diseases. Immunotherapy, 12 (5), 311-322. Recuperado de https://www.futuremedicine.com/doi/abs/10.2217/imt-2019-0096
Resource reference: https://www.futuremedicine.com/doi/pdf/10.2217/imt-2019-0096
Appears in Collections:Medicina

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