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https://repository.ucc.edu.co/handle/20.500.12494/15545| Title: | Thermodynamic analysis and preferential solvation of sulfamethazine in acetonitrile+ water cosolvent mixtures |
| Author: | Blanco Márquez, Joaquín H Caviedes Rubio, Diego Ivan Ortiz, Claudia Patricia Cerquera, Nestor Enrique Martínez, Fleming Delgado, Daniel Ricardo |
| Email autor: | danielr.delgado@campusucc.edu.co |
| metadata.dc.description.cvlac: | http://scienti.colciencias.gov.co:8081/cvlac/visualizador/generarCurriculoCv.do?cod_rh=0001402116 |
| Issue Date: | 1-Feb-2020 |
| Keywords: | Sulfamethazine Solubility Cosolvence Acetonitrile IKB |
| Resume: | This paper presents the solubility of sulfamethazine (SMT) in the acetonitrile (MeCN) + water (W) cosolvent system at nine temperatures. From the solubility experimental data, the thermodynamic functions of solution, mixing, and transfers are calculated and analyzed using the Perlovich graphical method. On the other hand, an enthalpy−entropy compensation analysis is performed and the preferential solvation parameters are calculated using the Kirkwood-Buff (IKBI) inverse integral method. The result of the performed calculations indicates that the SMT solution process is endothermic with entropic favor, where the addition of MeCN has a positive cosolvent effect between pure water and the mixture with w1 = 0.90. As for the preferential solvation, the SMT molecule is preferentially surrounded by water in water- and MeCN-rich mixtures, and in intermediate mixtures, the SMT molecule tends to be surrounded by MeCN. |
| Abstract: | This paper presents the solubility of sulfamethazine (SMT) in the acetonitrile (MeCN) + water (W) cosolvent system at nine temperatures. From the solubility experimental data, the thermodynamic functions of solution, mixing, and transfers are calculated and analyzed using the Perlovich graphical method. On the other hand, an enthalpy−entropy compensation analysis is performed and the preferential solvation parameters are calculated using the Kirkwood-Buff (IKBI) inverse integral method. The result of the performed calculations indicates that the SMT solution process is endothermic with entropic favor, where the addition of MeCN has a positive cosolvent effect between pure water and the mixture with w1 = 0.90. As for the preferential solvation, the SMT molecule is preferentially surrounded by water in water- and MeCN-rich mixtures, and in intermediate mixtures, the SMT molecule tends to be surrounded by MeCN. |
| Table Of Contents: | Abstract. -- Keywords. -- 1. Introduction. -- 2. Experimental. -- 3. Results and discussion. -- 4. Conclusions. -- Declaration of competing interest. -- Acknowledgment. -- References. -- |
| Program: | Ingeniería Industrial |
| Headquarters: | Neiva |
| Publisher: | Universidad Cooperativa de Colombia, Facultad de Ingenierías, Ingeniería Industrial, Neiva |
| metadata.dc.type: | Artículo |
| Citation: | Blanco-Márquez. J. H., Caviedes Rubio, D. I., Ortiz, C. P., Cequera, N. E., Martínez, F. y Delgado, D. R. (2020). Thermodynamic analysis and preferential solvation of sulfamethazine in acetonitrile + water cosolvent mixtures. Fluid Phase Equilibria Volume 505, 1 February 2020, 112361. |
| Resource reference: | https://www.sciencedirect.com/science/article/abs/pii/S0378381219304224 |
| Appears in Collections: | Ingeniería Industrial |
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|---|---|---|---|---|
| Thermodynamic analysis and preferential solvation of sulfamethazine in acetonitrile + water cosolvent mixtures.pdf Restricted Access | Artículo Científico | 1.21 MB | Adobe PDF | View/Open Request a copy |
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