Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12494/15545
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Title: Thermodynamic analysis and preferential solvation of sulfamethazine in acetonitrile+ water cosolvent mixtures
Author: Blanco Márquez, Joaquín H
Caviedes Rubio, Diego Ivan
Ortiz, Claudia Patricia
Cerquera, Nestor Enrique
Martínez, Fleming
Delgado, Daniel Ricardo
Email autor: danielr.delgado@campusucc.edu.co
metadata.dc.description.cvlac: http://scienti.colciencias.gov.co:8081/cvlac/visualizador/generarCurriculoCv.do?cod_rh=0001402116
Issue Date: 1-Feb-2020
Keywords: Sulfamethazine
Solubility
Cosolvence
Acetonitrile
IKB
Resume: This paper presents the solubility of sulfamethazine (SMT) in the acetonitrile (MeCN) + water (W) cosolvent system at nine temperatures. From the solubility experimental data, the thermodynamic functions of solution, mixing, and transfers are calculated and analyzed using the Perlovich graphical method. On the other hand, an enthalpy−entropy compensation analysis is performed and the preferential solvation parameters are calculated using the Kirkwood-Buff (IKBI) inverse integral method. The result of the performed calculations indicates that the SMT solution process is endothermic with entropic favor, where the addition of MeCN has a positive cosolvent effect between pure water and the mixture with w1 = 0.90. As for the preferential solvation, the SMT molecule is preferentially surrounded by water in water- and MeCN-rich mixtures, and in intermediate mixtures, the SMT molecule tends to be surrounded by MeCN.
Abstract: This paper presents the solubility of sulfamethazine (SMT) in the acetonitrile (MeCN) + water (W) cosolvent system at nine temperatures. From the solubility experimental data, the thermodynamic functions of solution, mixing, and transfers are calculated and analyzed using the Perlovich graphical method. On the other hand, an enthalpy−entropy compensation analysis is performed and the preferential solvation parameters are calculated using the Kirkwood-Buff (IKBI) inverse integral method. The result of the performed calculations indicates that the SMT solution process is endothermic with entropic favor, where the addition of MeCN has a positive cosolvent effect between pure water and the mixture with w1 = 0.90. As for the preferential solvation, the SMT molecule is preferentially surrounded by water in water- and MeCN-rich mixtures, and in intermediate mixtures, the SMT molecule tends to be surrounded by MeCN.
Table Of Contents: Abstract. -- Keywords. -- 1. Introduction. -- 2. Experimental. -- 3. Results and discussion. -- 4. Conclusions. -- Declaration of competing interest. -- Acknowledgment. -- References. --
Program: Ingeniería Industrial
Headquarters: Neiva
Type: Artículo
Citation: Blanco-Márquez. J. H., Caviedes Rubio, D. I., Ortiz, C. P., Cequera, N. E., Martínez, F. y Delgado, D. R. (2020). Thermodynamic analysis and preferential solvation of sulfamethazine in acetonitrile + water cosolvent mixtures. Fluid Phase Equilibria Volume 505, 1 February 2020, 112361.
Resource reference: https://www.sciencedirect.com/science/article/abs/pii/S0378381219304224
Appears in Collections:Ingeniería Industrial



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