Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12494/15428
Exportar a:
Title: Thermodynamic analysis of the solubility and preferential solvation of sulfamerazine in (acetonitrile + water) cosolvent mixtures at different temperatures
Author: Delgado, Daniel Ricardo
Blanco Márquez, Joaquín H.
Ortiz, Claudia P.
Cerquera, Nestor Enrique
Martínez, Fleming
Jouyban, Abolghasem
Email autor: danielr.delgado@campusucc.edu.co
metadata.dc.description.cvlac: http://scienti.colciencias.gov.co:8081/cvlac/visualizador/generarCurriculoCv.do?cod_rh=0001402116
Issue Date: 1-Nov-2019
Keywords: Sulfamerazine
van't Hoff equation
Cosolvent mixtures {acetonitrile + water}
Preferential solvation
IKBI
Resume: Solubility studies are valuable tools for the pharmaceutical industry and research centres and are currently becoming increasingly relevant in the environmental sciences field. This study presents the thermodynamic and preferential solvation analyses of solubility of sulfamerazine (SMR) in {acetonitrile (1) + water (2)} cosolvent mixtures at different temperatures (278.15–318.15 K). The maximum solubility of SMR was obtained at 318.15 K when mass fraction is w1 = 0.90, whereas the minimum solubility of SMR was obtained in pure water at 278.15 K. Based on the solubility data, the Gibbs and van't Hoff equations were used for obtaining the apparent thermodynamic dissolution functions, while the IKBI model was used for obtaining the preferential solvation coefficients. Thus, the dissolution process is endothermic and is heavily dependent on the polarity of the medium, favoring the entropy of thermodynamic solution functions in every case. With respect to the preferential solvation coefficients, the results indicate that SMR is preferentially hydrated in water- and acetonitrile-rich mixtures and that it is preferentially solvated by acetonitrile in mixtures having intermediate compositions (0.25 < x1 < 0.85). The Jouyban-Acree-van't Hoff model is applied for modeling the generated solubility data with reasonable accuracy.
Abstract: Solubility studies are valuable tools for the pharmaceutical industry and research centres and are currently becoming increasingly relevant in the environmental sciences field. This study presents the thermodynamic and preferential solvation analyses of solubility of sulfamerazine (SMR) in {acetonitrile (1) + water (2)} cosolvent mixtures at different temperatures (278.15–318.15 K). The maximum solubility of SMR was obtained at 318.15 K when mass fraction is w1 = 0.90, whereas the minimum solubility of SMR was obtained in pure water at 278.15 K. Based on the solubility data, the Gibbs and van't Hoff equations were used for obtaining the apparent thermodynamic dissolution functions, while the IKBI model was used for obtaining the preferential solvation coefficients. Thus, the dissolution process is endothermic and is heavily dependent on the polarity of the medium, favoring the entropy of thermodynamic solution functions in every case. With respect to the preferential solvation coefficients, the results indicate that SMR is preferentially hydrated in water- and acetonitrile-rich mixtures and that it is preferentially solvated by acetonitrile in mixtures having intermediate compositions (0.25 < x1 < 0.85). The Jouyban-Acree-van't Hoff model is applied for modeling the generated solubility data with reasonable accuracy.
Program: Ingeniería Industrial
Headquarters: Neiva
Type: Artículo
Citation: Joaquín H. Blanco-Márquez, Claudia P. Ortiz, Nestor Enrique Cerquera, Fleming Martínez, Abolghasem Jouyban, Daniel Ricardo Delgado, Thermodynamic analysis of the solubility and preferential solvation of sulfamerazine in (acetonitrile + water) cosolvent mixtures at different temperatures, Journal of Molecular Liquids, Volume 293, 2019, 111507, ISSN 0167-7322, https://doi.org/10.1016/j.molliq.2019.111507.
Resource reference: https://www.sciencedirect.com/science/article/abs/pii/S0167732219334932
Appears in Collections:Ingeniería Industrial

Files in This Item:
File Description SizeFormat 
2019_Thermodynamic_analysis_sulfamerazine.pdfArtículo Científico846.42 kBAdobe PDFView/Open Request a copy


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.