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Title: Tropism and molecular pathogenesis of Canine Distemper Virus
Author: Ruiz-Saenz, Julian
Rendon Marin, Santiago
da Fontoura Budaszewski, Renata
Wageck Canal, Cláudio
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Issue Date: 7-Mar-2019
Keywords: Canine distemper virus
Canine morbillivirus
Molecular pathogenesis
Resume: BACKGROUND: Canine distemper virus (CDV), currently termed Canine morbillivirus, is an extremely contagious disease that affects dogs. It is identified as a multiple cell tropism pathogen, and its host range includes a vast array of species. As a member of Mononegavirales, CDV has a negative, single-stranded RNA genome, which encodes eight proteins. MAIN BODY: Regarding the molecular pathogenesis, the hemagglutinin protein (H) plays a crucial role both in the antigenic recognition and the viral interaction with SLAM and nectin-4, the host cells' receptors. These cellular receptors have been studied widely as CDV receptors in vitro in different cellular models. The SLAM receptor is located in lymphoid cells; therefore, the infection of these cells by CDV leads to immunosuppression, the severity of which can lead to variability in the clinical disease with the potential of secondary bacterial infection, up to and including the development of neurological signs in its later stage. CONCLUSION: Improving the understanding of the CDV molecules implicated in the determination of infection, especially the H protein, can help to enhance the biochemical comprehension of the difference between a wide range of CDV variants, their tropism, and different steps in viral infection. The regions of interaction between the viral proteins and the identified host cell receptors have been elucidated to facilitate this understanding. Hence, this review describes the significant molecular and cellular characteristics of CDV that contribute to viral pathogenesis.
Program: Medicina veterinaria y zootecnia
Headquarters: Bucaramanga
Type: Artículo
Citation: Rendon Marin, S., Fontoura Budaszewski, R. D., Canal C. W., Ruiz Saenz, J. (2019) Tropism and molecular pathogenesis of Canine Distemper Virus. Virol J. 2019 Mar 7;16(1):30. DOI: 10.1186/s12985-019-1136-6
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Appears in Collections:Salud y Producción Animal

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