The development of the investigation was carried out taking as a population sample the paths Sucre, Guasimal, Paso Ancho and Dindalito of the municipality of El Espinal - Tolima, since they are areas with large tracts of land suitable for growing bread, where Studies carried out by members of the clinical toxicology team of the University of Nuestra Señora del Rosario (2012), have detected high levels of pesticides of the carbamate, organophosphate and organochlorine type, the latter being the type of pesticides most used in the maintenance of the culture of rice, therefore occurs at blood level in 100% of the individuals exposed directly (Briceño, Varona, & Crepy, 2012).