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Title: Preferential solvation of indomethacin in 1,4- dioxane + water mixtures according to the inverse Kirkwood–Buff integrals method
Author: Peña, María A.
Delgado, Daniel Ricardo
Martínez, Fleming
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Issue Date: 23-Nov-2015
Advisor / Validator: Delgado, Daniel Ricardo
Keywords: Indomethacin; 1-dioxane; solubility; inverse Kirkwood– Buff integrals; IKBI; preferential solvation
Resume: Artículo de investigación
Abstract: The preferential solvation parameters (δx1,3) of indomethacin (IMC) in 1,4-dioxane + water binary mixtures were derived from their thermo- dynamic properties by means of the inverse Kirkwood–Buff integrals method. δx1,3 is negative in water-rich and 1,4-dioxane-rich mixtures but positive in cosolvent compositions from 0.17 to 0.69 in mole fraction of 1,4-dioxane at 298.15 K. It is conjecturable that in water-rich mixtures, the hydrophobic hydration around the aromatic and methyl groups of the drug plays a relevant role in the solvation. The higher solvation by 1,4-dioxane in mixtures of similar cosolvent compositions could be mainly due to polarity effects. Finally, the preference of this drug for water in 1,4-dioxane-rich mixtures could be explained in terms of the higher acidic behavior of water molecules interacting with the hydrogen- acceptor groups present in IMC.
Table Of Contents: Introduction, Theoretical, Results and discussion, Conclusions, References
Program: Ingeniería Industrial
Headquarters: Neiva
Type: Artículo
CC Licence: Licencia CC
Citation: María Á. Peña, Daniel R. Delgado & Fleming Martínez (2016) Preferential solvation of indomethacin in 1,4-dioxane + water mixtures according to the inverse Kirkwood–Buff integrals method, Physics and Chemistry of Liquids, 54:4, 462-474, DOI: 10.1080/00319104.2015.1115329
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Appears in Collections:Ingeniería Industrial

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