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Title: Extended Hildebrand solubility approach applied to some sulphapyrimidines in some {methanol (1) + water (2)} mixtures
Author: Delgado, Daniel Ricardo
Peña, María A.
Martínez, Fleming
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Issue Date: 21-May-2017
Advisor / Validator: Delgado, Daniel Ricardo
Keywords: Sulphonamides; methanol; binary mixtures; extended Hildebrand solubility approach; Hildebrand solubility parameter
Resume: Articulo Científico
Abstract: Extended Hildebrand solubility approach (EHSA) was applied to analyse the equilibrium solubility of sulphadiazine, sulphamerazine and sulpha- methazine in some {methanol (1) + water (2)} mixtures at 298.15K. Reported experimental solubilities and some fusion properties of these drugs were used for EHSA calculations. A good predictive character of EHSA (with mean deviations lower than 4.0%) was found by using regular polynomials in order 4 when correlating the interaction para- meter (W) and the Hildebrand solubility parameter of solvent mixtures free of drug (δ1+2). Nevertheless, the predictive character of EHSA was almost the same as obtained when logarithmic drug solubilities (log x3) were correlated with δ1+2.
Table Of Contents: 1. Introduction, 2. Theoretical background, 3. Results and discussion, 4. Conclusion, References.
Program: Ingeniería Industrial
Headquarters: Neiva
Type: Artículo
CC Licence: Licencia CC
Citation: Daniel R. Delgado, María Á. Peña & Fleming Martínez (2017): Extended Hildebrand solubility approach applied to some sulphapyrimidines in some {methanol (1) + water (2)} mixtures, Physics and Chemistry of Liquids, DOI: 10.1080/00319104.2017.1317779
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Appears in Collections:Ingeniería Industrial

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