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dc.contributor.advisorDelgado, Daniel Ricardo-
dc.creatorCaviedes Rubio, Diego Iván-
dc.creatorDelgado, Daniel Ricardo-
dc.creatorRodríguez Rodríguez, Gerson Andrés-
dc.descriptionArticulo de investigaciónes
dc.description.abstractThe equilibrium solubilities of the anti-inflammatory drug naproxen (NPX) in 2-propanol + water mixtures were determined at several temperatures from 298.15 to 313.15 K. The Gibbs energy, enthalpy, and entropy of solution and of mixing were obtained from these solubility data. The solubility was maximal in φ1 = 0.90 and very low in pure water at all the temperatures studied. A non-linear plot of ∆solnH° vs. ∆solnG° with negative slope from pure water up to 0.20 in volume fraction of 2-propanol and positive beyond this composition up pure 2-propanol was obtained at the mean temperature, 305.55 K. Accordingly, the driving mechanism for NPX solubility in the water-rich mixtures was the entropy, probably due to water-structure loss around non-polar moieties of the drug and for the 2-propanol-rich mixtures it was the enthalpy, probably due to its better solvation of the
dc.publisherUniversidad Cooperativa de Colombia, Facultad de Ingenierías, Programa de Ingeniería Industrial, Neiva, Colombia, 00000es
dc.subjectnaproxen; solubility; thermodynamic of solutions; 2-propanoles
dc.titleThermodynamic Study of the Solubility of Naproxen in Some 2-Propanol + Water Mixtureses
dc.publisher.programIngeniería Industriales
dc.rights.ccLicencia CC
dc.identifier.bibliographicCitationDiego Iván Caviedes Rubio, Gerson Andrés Rodríguez Rodríguez, Daniel Ricardo Delgado. Thermodynamic Study of the Solubility of Naproxen in Some 2-Propanol + Water Mixtures. Revista Facultad de Ciencias Básicas. 12(1), 48-55-2016es
Appears in Collections:Ingeniería Industrial

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