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Title: Preferential Solvation of Indomethacin in Some Aqueous Co-Solvent Mixtures
Author: Peña, María A.
Delgado, Daniel Ricardo
Martínez, Fleming
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Issue Date: 4-Aug-2015
Advisor / Validator: Delgado, Daniel Ricardo
Keywords: Ethanol; Indomethacin; Inverse Kirkwood–Buff integrals (IKBI); Preferential Solvation; Propylene glycol; Quasi-lattice quasi-chemical (QLQC)
Resume: Artículo de investigación
Abstract: The preferential solvation parameters for indomethacin (IMC) in ethanol (EtOH) þ water and propylene glycol (PG) þ water binary mixtures were obtained from their thermodynamic properties by means of the inverse Kirkwood–Buff integrals (IKBI) and the quasi-lattice quasi-chemical (QLQC) methods. According to IKBI method, the preferential solvation parameter by co-solvents, (dx1,3), is negative in the water-rich mixtures of both binary systems but positive in the other compositions at temperatures of 293.15, 303.15, and 313.15 K. It is conjecturable that in water-rich mixtures the hydrophobic hydration around the aromatic rings and methyl groups of the drug plays a relevant role in the solvation. The higher drug solvation by co-solvent in mixtures of similar solvent proportion and in co-solvent-rich mixtures could be due mainly to polarity effects. Here IMC would be acting as a Lewis acid with the EtOH or PG molecules because these co-solvents are more basic than water.
Table Of Contents: Introduction, Theoretical Background, Results and Discussion, Conclusions, Nomenclature, References
Program: Ingeniería Industrial
Headquarters: Neiva
Type: Artículo
CC Licence: Licencia CC
Citation: María Á Peña, Daniel R. Delgado & Fleming Martínez (2016) Preferential Solvation of Indomethacin in Some Aqueous Co-Solvent Mixtures, Chemical Engineering Communications, 203:5, 619-627, DOI: 10.1080/00986445.2015.1074898
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Appears in Collections:Ingeniería Industrial

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