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Title: Study of Colombia North Wiwa El Encanto Amerindians HLA- genes: Pacific Islanders relatedness
Author: Arnaiz Villena, Antonio
Palacio Grüber, Jose
Juarez, Ignacio
Muñiz, Ester
Hernández Aguirre, Enio Armando
Bayona, Brayan
Campos, Cristina
Nuñez, Jorge
Lopez-Nares, Adrian
Martin-Villa, Manuel
Silvera, Carlos
Email autor: aarnaiz@med.ucm.es
enio.hernandez@campusucc.edu.co
Issue Date: Jul-2018
Keywords: HLA
Wiwa
Amerindians
Colombia
South America
America Peopling
Pharmacogenomics
Transplantation
Epidemiology
Abstract: We have studied Wiwa/Sanja Amerindians HLA-A, -B, -C, -DRB1 and DQB1 allele frequencies and extended haplotypes in 52 unrelated individuals from “El Encanto” town at Guanachaca riverside. High frequency alleles were in general present in other Amerindian populations. Also, three extended haplotypes and eight ones were respectively both “new found” and already described in Amerindians from North, Central and South America, including Lakota-Sioux, Mayas, Teeneks, Quechua and Aymaras. Analyses of HLA-A*24:02 and -C*01:02 Wiwa high frequency alleles suggested a specific relatedness with another Amerindian and Pacific Islander ethnic groups (these two particular alleles bearing in high frequencies); they include New Zealand Maoris, Taiwanese, Japanese, Papua New Guinea, and Samoans among others. This may indicate that selective forces are maintaining these two alleles high frequency within this wide American/Pacific area.
Program: Medicina
Headquarters: Santa Marta
Publisher: Universidad Cooperativa de Colombia, Facultad de Ciencias de la Salud, Medicina, Santa Marta
Type: Artículo
CC Licence: Licencia CC
Citation: Arnaiz, V. A., Palacio,G. J., Juareza, I., Hernández, E., Muñiz, E., Bayona, B., Campos, C., et al. (2018). Study of Colombia North Wiwa El Encanto Amerindians HLA- genes: Pacific Islanders relatedness. Human Immunology, 79, 530–531
Resource reference: https://doi.org/10.1016/j.humimm.2018.04.016
Appears in Collections:Medicina

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