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Title: Extended Hildebrand solubility approach applied to sulphadiazine, sulphamerazine and sulphamethazine in some {1-propanol (1) + water (2)} mixtures at 298.15 K
Author: Delgado, Daniel Ricardo
Peña, María Á.
Martínez, Fleming
Email autor: danielr.delgado@campusucc.edu.co
fmartinezr@unal.edu.co
Issue Date: 2018
Keywords: Sulphonamides
1-propanol
Binary mixtures
Extended Hildebrand solubility approach
EHSA
Hildebrand solubility parameter
Abstract: Extended Hildebrand solubility approach (EHSA) was applied in this research to analyse the equilibrium solubility of sulphadiazine, sulphamerazine and sulphamethazine in some {1-propanol (1) + water (2)} mixtures at 298.15 K. Reported experimental solubilities and some fusion properties of these drugs were used for EHSA calculations. A good predictive character of EHSA (with mean deviations lower than 4.0%) was found by using regular polynomials in order five when correlating the interaction parameter (W) and the Hildebrand solubility parameter of solvent mixtures free of drug (δ1+2). Nevertheless, the predictive character of EHSA was almost the same as obtained when logarithmic drug solubilities (log x3) were correlated with δ1+2 by using a fifth-degree regular polynomial.
Program: Ingeniería Industrial
Headquarters: Neiva
Publisher: Universidad Cooperativa de Colombia, Facultad de Ingenierías, Ingeniería Industrial, Neiva
Type: Artículo
CC Licence: Licencia CC
Citation: Delgado, D. R., Peña, M. Á., & Martínez, F. (2018). Extended Hildebrand solubility approach applied to sulphadiazine, sulphamerazine and sulphamethazine in some {1-propanol (1) + water (2)} mixtures at 298.15 K. Physics and Chemistry of Liquids, 56(2), 176-188. https://doi.org/10.1080/00319104.2017.1317779
Resource reference: https://doi.org/10.1080/00319104.2017.1317779
Appears in Collections:Ingeniería Industrial

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