Please use this identifier to cite or link to this item: http://repository.ucc.edu.co/handle/ucc/1361
Title: Actividad antiviral de compuestos aislados de esponjas marinas
Author: Gómez Archila, León G.
Rugeles, María T.
Zapata, Wildeman
Email autor: wildeman.zapatab@campusucc.edu.co
Issue Date: Dec-2014
Advisor / Validator: Zapata Builes, Wildeman
Keywords: Marine sponge;Antiviral activity;Herpes simplex virus (HSV);Human Immunodeficiency Virus Type 1 (HIV-1)
Abstract: Marine sponges have been used for the isolation and purification of compounds with therapeutic properties for human use. These compounds are used mainly against viruses because these microorganisms mutate and create resistance easily to available treatments. In the last 60 years, marine sponges have been the subject of scient ific research, which have addressed the discovery of compounds with activity against Herpes Simplex Virus (HSV) such as Ara-A; the avarol used against Human Immunodeficiency Virus Type 1 (HIV-1) and calyceramides against Influenza Virus. This article present a review of the chemistry and mechanism of action of the compounds isolated from marine sponges that have shown antiviral activity, to encourage the search for new molecules or their modification in order to obtain several sources of drug production and antiviral treatments. This review found that in vitro cell models have been the most used techniques and the HSV and HIV-1 are the main microorganisms studied for the determination of the antiviral activity; finally, it was found that the biological activities are directly related to the structure of the compounds, especially when they are analogs of amino acids or nucleotides.
Program: Medicina
Headquarters: Medellín
Publisher: Universidad Cooperativa de Colombia, Facultad de Ciencias de la Salud, Programa de Medicina, Medellín y Envigado, Colombia, 00000
Type: Artículo
CC Licence: Licencia CC
Citation: Gómez Archila, L. G, Rugeles, M. T., & Zapata, W. (2014). Actividad antiviral de compuestos aislados de esponjas marinas. Revista de biología marina y oceanografía, 49(3), 401-412. https://dx.doi.org/10.4067/S0718-19572014000300001
Resource reference: http://www.scielo.cl/pdf/revbiolmar/v49n3/art01.pdf
Appears in Collections:Medicina

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