Please use this identifier to cite or link to this item: http://repository.ucc.edu.co/handle/ucc/1349
Title: Antiviral molecules correlate with vitamin D pathway genes and are associated with natural resistance to HIV-1 infection
Author: Aguilar Jiménez, W.
Zapata, W.
Rugeles, M.
Email autor: wildeman.zapatab@campusucc.edu.co
Issue Date: Jul-2016
Advisor / Validator: Zapata Builes, Wildeman
Keywords: HIV-1;Natural resistance to HIV-1;HIV-1-exposed seronegative individuals (HESNs);Antiviral agents;Vitamin D
Abstract: The relationship between the immunomodulatory effects of Vitamin D (VitD) and the expression of anti-HIV-1 molecules has not been explored in HIV-1-exposed seronegative individuals (HESNs). Higher mRNA levels of cathelicidin and HAD-4 in oral-mucosa and peripheralblood, along with higher CYP24A1 mRNA in vaginal-mucosa and lower TLR2 mRNA in endocervical-mucosa were found in HESNs compared to non-exposed controls. Furthermore, the mRNA of anti-HIV molecules Elafin, TRIM5, Cathelicidin, HAD-4 and RNase7, previously associated with natural resistance to HIV-1 infection, positively correlated with the mRNA expression of VDR in HESNs, suggesting the potential participation of VitD in natural resistance to HIV-1.
Program: Medicina
Headquarters: Medellín
Publisher: Universidad Cooperativa de Colombia, Facultad de Ciencias de la Salud, Programa de Medicina, Medellín y Envigado, Colombia, 00000
Type: Artículo
CC Licence: Licencia CC
Citation: Aguilar Jimenez, W., Zapata W., & Rugeles M. (2016). Antiviral molecules correlate with vitamin D pathway genes and are associated with natural resistance to HIV-1 infection. Microbes and Infect, ;18(7-8), 510–516.
Resource reference: http://www.sciencedirect.com/science/article/pii/S1286457916300272?via%3Dihub
Appears in Collections:Medicina

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