Please use this identifier to cite or link to this item: http://repository.ucc.edu.co/handle/ucc/1190
Title: HIV-1–neutrophil interactions trigger neutrophil activation and Toll-like receptor expression
Author: Giraldo, Diana M.
Hernández, Juan C.
Velilla, Paula A.
Urcuqui Inchima, Silvio
Email autor: juanc.hernandezl@campusucc.edu.co
Issue Date: Feb-2016
Advisor / Validator: Hernández, Juan C.
Keywords: Neutrophils;HIV-1
Abstract: Although neutrophils are the first-line of host defense against infection and express a wide number of pattern recognition receptors (PRRs), the function of these PRRs, including Toll-like receptors (TLRs), in HIV-1 infection remains unclear. TLRs play an important role in innate immunity, and while their involvement in viral immune pathogenesis was recently proposed, little is known about their expression and function during the neutrophil response to HIV-1 exposure. Here, we have shown that freshly isolated human neutrophils from healthy donors exhibited altered TLR expression, which may affect their function, after being challenged with HIV-1, alone or in the presence of TLR agonists. TLRs may promote neutrophil activation, pro-inflammatory cytokine secretion, and the production of reactive oxygen species. To our knowledge, this study is the first demonstration of functional TLR expression on neutrophils in response to HIV-1 treatment, suggesting a possible neutrophil/HIV-1 interaction through TLRs. Although additional studies are required to confirm the function of TLRs in neutrophils, our data clearly suggest that they play a role in the regulation of innate immunity by neutrophils, which could be engaged in HIV-1 pathogenesis or host defense.
Program: Medicina
Headquarters: Medellín
Publisher: Universidad Cooperativa de Colombia, Facultad de Ciencias de la Salud, Programa de Medicina, Medellín y Envigado, Colombia, 00000
Type: Artículo
CC Licence: Licencia CC
Citation: Giraldo D. M, Hernández J. C., Velilla P. & Urcuqui Inchima S. (2016). HIV-1–neutrophil interactions trigger neutrophil activation and Toll-like receptor expression. Immunologic Research, 64(1), 93-103. doi: 10.1007/s12026-015-8691-8
Resource reference: https://link.springer.com/article/10.1007%2Fs12026-015-8691-8
Appears in Collections:Medicina

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