Please use this identifier to cite or link to this item: http://repository.ucc.edu.co/handle/ucc/1176
Title: Short Communication: Low expression of activation and inhibitory molecules on NK cells and CD4+ T-cells is associated with viral control
Author: Taborda, Natalia
Hernández, Juan C.
Lajoie, Julie
Juno, Jennifer
Kimani, Josua
Rugeles, María Teresa
Fowke, Keith R.
Email autor: juanc.hernandezl@campusucc.edu.co
Issue Date: May-2015
Advisor / Validator: Hernández, Juan C.
Keywords: NK cells;Viral control;Enfermedades infecciosas
Abstract: Chronic HIV-1 infection induces severe immune alterations, including hyperactivation, exhaustion and apoptosis. In fact, viral control has been associated with low frequencies of these processes. Here, we evaluated the expression of activation and inhibitory molecules on NK and CD4+ T-cells in individuals exhibiting viral control: a cohort of HIV-1-exposed-seronegative individuals (HESN) and a cohort of HIV-controllers. There was lower expression of CD69, LAG-3, PD-1 and TIM-3 in both cohorts when compared to a low-risk population or HIV-progressors. These findings suggest that individuals exhibiting viral control have lower basal expression of markers associated with cellular activation and particularly immune exhaustion.
Program: Medicina
Headquarters: Medellín
Publisher: Universidad Cooperativa de Colombia, Facultad de Ciencias de la Salud, Programa de Medicina, Medellín y Envigado, Colombia, 00000
Type: Artículo
CC Licence: Licencia CC
Citation: Taborda, N., Hernández, J. C., Lajoie. J., Juno, J., Kimani. J., Rugeles, M. T. & Fowke, K. R. (2015). Low expression of activation and inhibitory molecules on NK cells and CD4+ T-cells is associated with viral control. AIDS Res Hum Retroviruses. 31(6), 636-640. doi: 10.1089/AID.2014.0325
Resource reference: http://online.liebertpub.com/doi/10.1089/aid.2014.0325
Appears in Collections:Medicina

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