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|Title:||Short Communication: Low expression of activation and inhibitory molecules on NK cells and CD4+ T-cells is associated with viral control|
Hernández, Juan C.
Rugeles, María Teresa
Fowke, Keith R.
|Advisor / Validator:||Hernández, Juan C.|
|Keywords:||NK cells;Viral control;Enfermedades infecciosas|
|Abstract:||Chronic HIV-1 infection induces severe immune alterations, including hyperactivation, exhaustion and apoptosis. In fact, viral control has been associated with low frequencies of these processes. Here, we evaluated the expression of activation and inhibitory molecules on NK and CD4+ T-cells in individuals exhibiting viral control: a cohort of HIV-1-exposed-seronegative individuals (HESN) and a cohort of HIV-controllers. There was lower expression of CD69, LAG-3, PD-1 and TIM-3 in both cohorts when compared to a low-risk population or HIV-progressors. These findings suggest that individuals exhibiting viral control have lower basal expression of markers associated with cellular activation and particularly immune exhaustion.|
|Publisher:||Universidad Cooperativa de Colombia, Facultad de Ciencias de la Salud, Programa de Medicina, Medellín y Envigado, Colombia, 00000|
|CC Licence:||Licencia CC|
|Citation:||Taborda, N., Hernández, J. C., Lajoie. J., Juno, J., Kimani. J., Rugeles, M. T. & Fowke, K. R. (2015). Low expression of activation and inhibitory molecules on NK cells and CD4+ T-cells is associated with viral control. AIDS Res Hum Retroviruses. 31(6), 636-640. doi: 10.1089/AID.2014.0325|
|Appears in Collections:||Medicina|
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