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Title: Extended Hildebrand solubility approach applied to some structurally related sulfonamides in ethanol + water mixtures
Author: Delgado, Daniel Ricardo
Peña, María A.
Martínez, Fleming
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Issue Date: 2016
Keywords: Hildebrand solubility approach
Binary mixtures
Hildebrand solubility parameter
Description: Artículo publicado en acceso abierto en la revista: Revista Colombiana de Química. ISSN Impreso: 0120-2804. ISSN En línea: 2357-3791. Universidad Nacional de Colombia. Bogotá, Colombia.
Abstract: Extended Hildebrand Solubility Approach (EHSA) was applied to evaluate the solubility of sulfadiazine, sulfamerazine, and sulfamethazine in some ethanol + water mixtures at 298.15 K. Reported experimental equilibrium solubilities and some fusion properties of these drugs were used for the calculations. In particular, a good predictive character of EHSA (with mean deviations lower than 3.0%) has been found by using regular polynomials in order four correlating the interaction parameter W with the Hildebrand solubility parameter of solvent mixtures without drug. However, the predictive character of EHSA was the same as that obtained by direct correlation of drug solubilities with the same descriptor of polarity of the cosolvent mixtures.
Program: Ingeniería Industrial
Headquarters: Neiva
Publisher: Universidad Cooperativa de Colombia, Facultad de Ingenierías, Programa de Ingeniería Industrial, Neiva, Colombia, 00000
Type: Artículo
CC Licence: Licencia CC
Citation: Delgado, D. R., Peña, M., & Martínez, F. (2016). Extended Hildebrand solubility approach applied to some structurally related sulfonamides in ethanol + water mixtures. Revista Colombiana de Química, 45(1), 34-43. doi:
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