Please use this identifier to cite or link to this item: http://repository.ucc.edu.co/handle/ucc/1024
Title: Thermodynamic Study of the Solubility of Naproxen in Some 2-Propanol + Water Mixtures
Author: Caviedes Rubio, Diego Iván
Delgado, Daniel Ricardo
Rodríguez Rodríguez, Gerson Andrés
Email autor: danielr.delgado@campusucc.edu.co
Issue Date: 14-Mar-2016
Advisor / Validator: Delgado, Daniel Ricardo
Keywords: naproxen; solubility; thermodynamic of solutions; 2-propanol
Description: Articulo de investigación
Abstract: The equilibrium solubilities of the anti-inflammatory drug naproxen (NPX) in 2-propanol + water mixtures were determined at several temperatures from 298.15 to 313.15 K. The Gibbs energy, enthalpy, and entropy of solution and of mixing were obtained from these solubility data. The solubility was maximal in φ1 = 0.90 and very low in pure water at all the temperatures studied. A non-linear plot of ∆solnH° vs. ∆solnG° with negative slope from pure water up to 0.20 in volume fraction of 2-propanol and positive beyond this composition up pure 2-propanol was obtained at the mean temperature, 305.55 K. Accordingly, the driving mechanism for NPX solubility in the water-rich mixtures was the entropy, probably due to water-structure loss around non-polar moieties of the drug and for the 2-propanol-rich mixtures it was the enthalpy, probably due to its better solvation of the drug.
Table Of Contents: INTRODUCTION, RESULTS AND DISCUSSION, CONCLUSIONS, REFERENCES
Program: Ingeniería Industrial
Headquarters: Neiva
Publisher: Universidad Cooperativa de Colombia, Facultad de Ingenierías, Programa de Ingeniería Industrial, Neiva, Colombia, 00000
Type: Artículo
CC Licence: Licencia CC
Citation: Diego Iván Caviedes Rubio, Gerson Andrés Rodríguez Rodríguez, Daniel Ricardo Delgado. Thermodynamic Study of the Solubility of Naproxen in Some 2-Propanol + Water Mixtures. Revista Facultad de Ciencias Básicas. 12(1), 48-55-2016
Resource reference: https://revistas.unimilitar.edu.co/index.php/rfcb/article/view/1853/1493
Appears in Collections:Ingeniería Industrial

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